Aldo-keto reductase family 1 member C3

NameAldo-keto reductase family 1 member C3
Synonyms
  • 1.-.-.-
  • 17-beta-HSD 5
  • 17-beta-hydroxysteroid dehydrogenase type 5
  • 3-alpha-HSD type 2
  • 3-alpha-HSD type II, brain
  • 3-alpha-hydroxysteroid dehydrogenase type 2
  • Chlordecone reductase homolog HAKRb
  • DD-3
  • DD3
  • DDH1
  • Dihydrodiol dehydrogenase 3
  • Dihydrodiol dehydrogenase type I
  • HA1753
  • HSD17B5
  • Indanol dehydrogenase
  • KIAA0119
  • PGFS
  • Prostaglandin F synthase
  • Testosterone 17-beta-dehydrogenase 5
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Gene NameAKR1C3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037052|Aldo-keto reductase family 1 member C3
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
Number of residues323
Molecular Weight36852.89
Theoretical pI8.06
GO Classification
Functions
  • phenanthrene 9,10-monooxygenase activity
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
  • geranylgeranyl reductase activity
  • testosterone dehydrogenase (NAD+) activity
  • alditol
  • 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
  • retinol dehydrogenase activity
  • dihydrotestosterone 17-beta-dehydrogenase activity
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
  • ketoreductase activity
  • aldo-keto reductase (NADP) activity
  • testosterone 17-beta-dehydrogenase (NADP+) activity
  • prostaglandin D2 11-ketoreductase activity
  • prostaglandin-F synthase activity
  • delta4-3-oxosteroid 5beta-reductase activity
  • indanol dehydrogenase activity
  • retinal dehydrogenase activity
  • androsterone dehydrogenase activity
  • ketosteroid monooxygenase activity
Processes
  • response to nutrient
  • cellular response to reactive oxygen species
  • small molecule metabolic process
  • retinoid metabolic process
  • cellular response to jasmonic acid stimulus
  • male gonad development
  • farnesol catabolic process
  • daunorubicin metabolic process
  • doxorubicin metabolic process
  • progesterone metabolic process
  • positive regulation of protein kinase B signaling
  • oxidation-reduction process
  • renal absorption
  • cellular response to prostaglandin D stimulus
  • steroid metabolic process
  • cellular response to corticosteroid stimulus
  • G-protein coupled receptor signaling pathway
  • cellular response to cadmium ion
  • protein import into nucleus, translocation
  • cellular response to prostaglandin stimulus
  • positive regulation of cell proliferation
  • keratinocyte differentiation
  • multicellular organismal macromolecule metabolic process
  • negative regulation of retinoic acid biosynthetic process
  • positive regulation of reactive oxygen species metabolic process
  • cellular response to starvation
  • regulation of testosterone biosynthetic process
  • phototransduction, visible light
  • cyclooxygenase pathway
  • testosterone biosynthetic process
  • positive regulation of endothelial cell apoptotic process
  • prostaglandin metabolic process
  • cellular response to calcium ion
  • retinal metabolic process
  • positive regulation of cell death
  • arachidonic acid metabolic process
  • regulation of retinoic acid receptor signaling pathway
Components
  • nucleus
  • cytosol
  • extracellular exosome
  • intracellular
  • cytoplasm
General FunctionTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific FunctionCatalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID4261711
UniProtKB IDP42330
UniProtKB Entry NameAK1C3_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0018982|Aldo-keto reductase family 1 member C3 (AKR1C3)
ATGGATTCAAAACATCAGTGTTTGAAGCTAAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA
GenBank Gene IDS68288
GeneCard IDNot Available
GenAtlas IDAKR1C3
HGNC IDHGNC:386
Chromosome Location10
Locus10p15-p14
References
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