Melanocortin receptor 3

NameMelanocortin receptor 3
Synonyms
  • MC3-R
Gene NameMC3R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009850|Melanocortin receptor 3
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
Number of residues323
Molecular Weight36042.75
Theoretical pINot Available
GO Classification
Functions
  • melanocortin receptor activity
  • peptide hormone binding
  • neuropeptide binding
  • melanocyte-stimulating hormone receptor activity
Processes
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • positive regulation of cAMP biosynthetic process
  • sodium ion homeostasis
  • regulation of heart rate
  • regulation of blood pressure
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • regulation of feeding behavior
  • circadian regulation of gene expression
  • locomotor rhythm
  • homoiothermy
Components
  • integral component of plasma membrane
  • plasma membrane
General FunctionPeptide hormone binding
Specific FunctionReceptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Pfam Domain Function
Transmembrane Regions38-63 76-100 119-140 161-181 187-210 246-268 278-301
GenBank Protein IDNot Available
UniProtKB IDP41968
UniProtKB Entry NameMC3R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013948|Melanocortin receptor 3 (MC3R)
ATGAATGCTTCGTGCTGCCTGCCCTCTGTTCAGCCAACACTGCCTAATGGCTCGGAGCAC
CTCCAAGCCCCTTTCTTCAGCAACCAGAGCAGCAGCGCCTTCTGTGAGCAGGTCTTCATC
AAGCCCGAGGTTTTCCTGTCTCTGGGCATCGTCAGTCTGCTGGAAAACATCCTGGTTATC
CTGGCCGTGGTCAGGAACGGCAACCTGCACTCCCCGATGTACTTCTTTCTCTGCAGCCTG
GCGGTGGCCGACATGCTGGTAAGTGTGTCCAATGCCCTGGAGACCATCATGATCGCCATC
GTCCACAGCGACTACCTGACCTTCGAGGACCAGTTTATCCAGCACATGGACAACATCTTC
GACTCCATGATCTGCATCTCCCTGGTGGCCTCCATCTGCAACCTCCTGGCCATCGCCGTC
GACAGGTACGTCACCATCTTTTACGCGCTCCGCTACCACAGCATCATGACCGTGAGGAAG
GCCCTCACCTTGATCGTGGCCATCTGGGTCTGCTGCGGCGTCTGTGGCGTGGTGTTCATC
GTCTACTCGGAGAGCAAAATGGTCATTGTGTGCCTCATCACCATGTTCTTCGCCATGATG
CTCCTCATGGGCACCCTCTACGTGCACATGTTCCTCTTTGCGCGGCTGCACGTCAAGCGC
ATAGCAGCACTGCCACCTGCCGACGGGGTGGCCCCACAGCAACACTCATGCATGAAGGGG
GCAGTCACCATCACCATTCTCCTGGGCGTGTTCATCTTCTGCTGGGCCCCCTTCTTCCTC
CACCTGGTCCTCATCATCACCTGCCCCACCAACCCCTACTGCATCTGCTACACTGCCCAC
TTCAACACCTACCTGGTCCTCATCATGTGCAACTCCGTCATCGACCCACTCATCTACGCT
TTCCGGAGCCTGGAATTGCGCAACACCTTTAGGGAGATTCTCTGTGGCTGCAACGGCATG
AACTTGGGATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6931
Chromosome Location20
LocusNot Available
References
  1. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T: Molecular cloning of a novel melanocortin receptor. J Biol Chem. 1993 Apr 15;268(11):8246-50. 8463333
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  4. Tarnow P, Rediger A, Schulz A, Gruters A, Biebermann H: Identification of the translation start site of the human melanocortin 3 receptor. Obes Facts. 2012;5(1):45-51. doi: 10.1159/000336070. Epub 2012 Mar 2. 22433616
  5. Lee YS, Poh LK, Loke KY: A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. J Clin Endocrinol Metab. 2002 Mar;87(3):1423-6. 11889220
  6. Tao YX, Segaloff DL: Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab. 2004 Aug;89(8):3936-42. 15292330
  7. Mencarelli M, Walker GE, Maestrini S, Alberti L, Verti B, Brunani A, Petroni ML, Tagliaferri M, Liuzzi A, Di Blasio AM: Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. Eur J Hum Genet. 2008 May;16(5):581-6. doi: 10.1038/sj.ejhg.5202005. Epub 2008 Jan 30. 18231126