NameC-C chemokine receptor type 2
Synonyms
  • C-C CKR-2
  • CMKBR2
  • MCP-1-R
  • Monocyte chemoattractant protein 1 receptor
Gene NameCCR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006609|C-C chemokine receptor type 2
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Number of residues374
Molecular Weight41914.265
Theoretical pI9.25
GO Classification
Functions
  • C-C chemokine receptor activity
  • protein homodimerization activity
  • CCR2 chemokine receptor binding
  • chemokine receptor activity
Processes
  • cytokine-mediated signaling pathway
  • immune response
  • negative regulation of angiogenesis
  • cellular calcium ion homeostasis
  • positive regulation of immune complex clearance by monocytes and macrophages
  • negative regulation of adenylate cyclase activity
  • inflammatory response
  • positive regulation of T cell activation
  • regulation of vascular endothelial growth factor production
  • positive regulation of monocyte chemotaxis
  • chemotaxis
  • positive regulation of tumor necrosis factor biosynthetic process
  • cellular defense response
  • positive regulation of T cell chemotaxis
  • positive regulation of alpha-beta T cell proliferation
  • positive regulation of hematopoietic stem cell migration
  • positive regulation of interferon-gamma production
  • positive regulation of T-helper 1 type immune response
  • JAK-STAT cascade
  • negative regulation of eosinophil degranulation
  • viral process
  • innate immune response
  • negative regulation of type 2 immune response
  • blood vessel remodeling
  • positive regulation of cytosolic calcium ion concentration
  • positive regulation of astrocyte chemotaxis
  • positive regulation of interleukin-2 production
  • positive regulation of CD8-positive, alpha-beta T cell extravasation
  • positive regulation of monocyte extravasation
  • chemokine-mediated signaling pathway
  • T-helper 17 cell chemotaxis
  • dendritic cell chemotaxis
  • response to wounding
  • positive regulation of inflammatory response
  • cellular homeostasis
Components
  • plasma membrane
  • neuronal cell body
  • integral component of membrane
  • cytosol
  • perinuclear region of cytoplasm
  • integral component of plasma membrane
  • dendrite
  • cytoplasm
  • perikaryon
General FunctionProtein homodimerization activity
Specific FunctionReceptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
Pfam Domain Function
Transmembrane Regions43-70 81-100 115-136 154-178 207-226 244-268 286-309
GenBank Protein IDNot Available
UniProtKB IDP41597
UniProtKB Entry NameCCR2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017084|C-C chemokine receptor type 2 (CCR2)
ATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTC
ACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATT
GGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAAC
ATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTAC
CTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCAC
TCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTAT
CACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTG
GCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACA
AGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAA
TGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAAT
TTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATC
TGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGG
GCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAAT
ATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACC
AGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATC
AATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGCCTTTTTCACATAGCTCTT
GGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGGAGTGAGACCAGGA
AAGAATGTGAAAGTGACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATT
GGCAGAGCCCCTGAAGCCAGTCTTCAGGACAAAGAAGGAGCCTAG
GenBank Gene IDU03882
GeneCard IDNot Available
GenAtlas IDCCR2
HGNC IDHGNC:1603
Chromosome Location3
Locus3p21.31
References
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  2. Yamagami S, Tokuda Y, Ishii K, Tanaka H, Endo N: cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Biochem Biophys Res Commun. 1994 Jul 29;202(2):1156-62. 8048929
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