Lysine-specific demethylase 5C
Name | Lysine-specific demethylase 5C |
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Synonyms |
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Gene Name | KDM5C |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037293|Lysine-specific demethylase 5C MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG AGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSH SPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTEL VEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMP VLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSL AAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRA YHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDL NLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALA CYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVA LEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGP HRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGL LQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASV APSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQ ALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHS WREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDL RDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGAL QCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILA LLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPR PEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSL LPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLEL EKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEE ETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL |
Number of residues | 1560 |
Molecular Weight | 175718.565 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Zinc ion binding |
Specific Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
Pfam Domain Function | |
Transmembrane Regions | Not Available |
GenBank Protein ID | Not Available |
UniProtKB ID | P41229 |
UniProtKB Entry Name | KDM5C_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0021734|Lysine-specific demethylase 5C (KDM5C) ATGGAGCCGGGGTCCGACGATTTCCTACCGCCACCGGAGTGCCCGGTGTTCGAGCCTAGC TGGGCCGAGTTCCGAGACCCTCTTGGCTACATCGCGAAAATCAGGCCCATCGCAGAGAAA TCGGGCATTTGCAAGATCCGCCCACCCGCGATTGTGGTGGAGGAAGGTGGTTATGAAGCT ATCTGCAAGGACCGTCGGTGGGCTCGGGTAGCCCAGCGCCTCAACTATCCACCAGGCAAA AATATTGGCTCCTTGCTACGCTCCCACTACGAACGCATTGTTTATCCCTATGAAATGTAC CAGTCTGGAGCCAACCTTGTGCAGTGTAACACACGTCCATTTGATAATGAGGAGAAGGAC AAGGAATACAAACCCCACAGCATCCCCCTACGACAGTCTGTGCAGCCTTCCAAGTTCAAC AGCTATGGCCGGCGGGCCAAGAGACTGCAGCCTGATCCGGAACCCACAGAGGAAGACATT GAGAAGAATCCAGAGCTGAAAAAGCTACAGATCTATGGGGCAGGCCCCAAGATGATGGGC CTGGGCCTCATGGCCAAAGACAAGACTCTGCGGAAGAAAGATAAGGAGGGGCCTGAGTGT CCCCCCACAGTAGTGGTGAAGGAGGAGTTAGGTGGGGATGTGAAGGTGGAGTCAACATCG CCTAAGACCTTCCTGGAGAGCAAGGAGGAGCTGAGTCACAGCCCAGAACCCTGCACCAAG ATGACCATGAGGCTACGGAGGAACCACAGCAATGCCCAGTTTATTGAGTCATATGTCTGC CGGATGTGTTCTCGAGGGGATGAGGATGACAAGCTCCTGCTGTGTGATGGCTGTGATGAC AACTACCACATCTTCTGCCTGCTGCCTCCTCTGCCTGAGATCCCCAAGGGTGTCTGGCGG TGCCCAAAGTGTGTCATGGCGGAGTGTAAGCGGCCCCCAGAAGCCTTTGGCTTTGAGCAG GCTACCCGGGAATACACTCTGCAGAGCTTTGGCGAGATGGCCGACTCCTTTAAAGCTGAC TACTTCAACATGCCCGTGCATATGGTGCCCACAGAACTTGTGGAGAAGGAGTTCTGGAGG CTGGTAAATAGCATTGAGGAAGATGTGACTGTTGAGTATGGAGCTGACATCCATTCCAAA GAATTTGGCAGCGGTTTCCCTGTCAGTGACAGTAAACGGCACCTAACCCCCGAAGAGGAG GAGTATGCTACCAGTGGTTGGAACCTAAATGTGATGCCGGTGTTGGAACAGTCTGTACTG TGCCACATCAATGCAGATATCTCTGGCATGAAGGTGCCCTGGCTCTACGTGGGCATGGTC TTCTCAGCCTTTTGCTGGCATATTGAGGATCACTGGAGTTACTCCATTAACTACCTCCAC TGGGGTGAGCCGAAGACCTGGTATGGGGTGCCCTCACTTGCAGCAGAACATTTGGAAGAA GTGATGAAGAAGCTGACACCTGAACTATTTGATAGCCAGCCTGACCTCCTGCACCAACTT GTCACCCTCATGAATCCCAACACCCTCATGTCCCATGGTGTGCCAGTTGTCCGCACAAAC CAGTGTGCAGGAGAGTTTGTCATCACCTTCCCCCGTGCTTACCACAGCGGCTTCAACCAA GGCTACAACTTTGCCGAGGCTGTCAACTTTTGCACTGCTGACTGGTTGCCTGCTGGGCGC CAGTGCATTGAGCACTACCGCCGGCTCCGGAGATACTGCGTCTTCTCCCATGAGGAGCTT ATCTGCAAGATGGCTGCCTGCCCAGAGAAGCTAGACCTGAACCTGGCGGCAGCTGTGCAT AAGGAGATGTTCATCATGGTGCAAGAAGAGCGGCGTCTACGAAAGGCCCTGCTGGAGAAG GGTATCACAGAGGCTGAGCGAGAGGCTTTCGAGCTGCTCCCAGATGATGAGCGCCAGTGT ATCAAGTGCAAGACTACGTGTTTCCTGTCAGCCCTGGCCTGCTACGACTGCCCAGACGGC CTTGTCTGCCTTTCCCACATCAATGATCTCTGCAAGTGCTCCAGTAGCCGGCAGTACCTG CGGTATCGGTATACCTTGGATGAGCTTCCTGCCATGCTGCATAAGCTGAAGGTTCGGGCT GAGTCCTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCCTGGAGGTGGAGGATGGGCGG AAGCGCAGCCTTGAAGAACTGAGGGCACTAGAGTCTGAAGCCCGTGAGCGGAGGTTTCCT AATAGTGAGCTGCTGCAGCAACTAAAGAACTGCCTGAGTGAGGCAGAGGCTTGCGTGTCC CGAGCTCTGGGACTGGTCAGCGGCCAGGAAGCTGGCCCCCACAGGGTGGCTGGTCTACAG ATGACCCTGACTGAGCTCCGGGCCTTTCTGGACCAGATGAACAACCTGCCTTGCGCCATG CACCAGATTGGGGATGTCAAGGGTGTTCTGGAACAGGTGGAGGCCTACCAGGCTGAGGCT CGTGAGGCCCTGGCCTCACTGCCCTCCAGTCCAGGGCTACTGCAGTCCCTGTTGGAGAGG GGGCGGCAGCTGGGGGTGGAGGTGCCTGAGGCCCAGCAGCTCCAGCGGCAGGTGGAACAG GCGCGATGGCTGGATGAGGTGAAACGCACACTGGCCCCCTCAGCCCGAAGGGGCACCTTG GCTGTCATGCGAGGACTGTTGGTCGCGGGTGCCAGTGTAGCCCCTAGCCCTGCTGTGGAT AAAGCCCAGGCCGAGCTGCAGGAACTGCTGACCATTGCTGAACGCTGGGAGGAGAAAGCC CACCTCTGCCTGGAGGCCAGGCAGAAGCATCCACCAGCCACACTTGAGGCCATAATCCGT GAAGCGGAAAACATCCCTGTTCACCTGCCCAACATCCAGGCTCTCAAGGAGGCTCTTGCT AAGGCCCGGGCCTGGATTGCTGATGTTGATGAGATCCAAAATGGTGACCACTACCCCTGC CTGGATGACTTGGAGGGCCTAGTAGCTGTGGGCCGGGACCTACCTGTGGGGCTGGAGGAG CTGAGACAGCTAGAGCTACAGGTACTGACAGCGCACTCCTGGAGGGAGAAGGCCTCCAAG ACCTTCCTCAAGAAAAATTCTTGCTACACGCTGCTGGAGGTTCTCTGCCCATGTGCAGAT GCCGGCTCAGACAGCACCAAGCGCAGCCGGTGGATGGAGAAGGAGCTGGGGTTGTACAAA TCTGACACAGAGCTGCTGGGGCTGTCTGCGCAGGACCTCAGGGACCCAGGCTCTGTGATC GTGGCCTTCAAGGAGGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACC AATTCGGCCAAGCCCAGTCCACTGGCATCATCGAGCACGGCCTCCTCTACAACCTCTATC TGTGTGTGTGGGCAGGTGCTGGCTGGGGCGGGAGCTCTGCAGTGTGACCTGTGTCAGGAC TGGTTCCATGGGCGGTGTGTGTCAGTGCCTCGCCTCCTCAGCTCTCCGAGGCCCAATCCC ACCTCATCCCCACTGCTGGCCTGGTGGGAATGGGACACCAAATTCCTGTGTCCACTGTGT ATGCGCTCAAGGCGCCCGCGCCTGGAGACCATCCTGGCACTGCTGGTAGCCCTGCAGAGA CTGCCTGTGCGGCTGCCCGAGGGCGAGGCCCTGCAGTGCCTCACAGAGAGGGCCATCAGC TGGCAAGGCCGCGCCAGGCAGGCTCTGGCCTCTGAAGATGTGACTGCTCTTTTGGGACGG CTGGCTGAGCTCCGCCAACGGCTACAGGCTGAACCTAGACCTGAGGAGCCTCCTAACTAC CCTGCAGCCCCTGCTTCTGACCCCCTCAGAGAGGGCAGTGGCAAGGATATGCCTAAGGTC CAGGGCTTACTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAAGGTAGCCCCGGAGGAG GGCTCAGATCTGGAGCTGCTGTCCTCGCTGTTGCCACAGTTGACTGGCCCTGTGTTGGAA CTGCCTGAGGCAACCCGGGCCCCCTTGGAGGAGCTCATGATGGAGGGGGACCTGCTCGAG GTGACCCTGGATGAGAACCACAGCATCCCTGAGTCCCTTGACTTTTGTATTCTGACTCCA AGGTATTGTTCAGACCTCAGCTCCTGGGGGCCGGCCCCTGGAGTCTTCCCTCCCTGGTAG |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:11114 |
Chromosome Location | X |
Locus | Not Available |
References |
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