Peroxisome proliferator-activated receptor gamma

NamePeroxisome proliferator-activated receptor gamma
Synonyms
  • NR1C3
  • Nuclear receptor subfamily 1 group C member 3
  • PPAR-gamma
Gene NamePPARG
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000429|Peroxisome proliferator-activated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
Number of residues505
Molecular Weight57619.58
Theoretical pI5.77
GO Classification
Functions
  • ligand-dependent nuclear receptor transcription coactivator activity
  • steroid hormone receptor activity
  • DNA binding
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
  • alpha-actinin binding
  • transcription regulatory region DNA binding
  • chromatin binding
  • enzyme binding
  • activating transcription factor binding
  • arachidonic acid binding
  • transcription factor activity, sequence-specific DNA binding
  • core promoter sequence-specific DNA binding
  • RNA polymerase II regulatory region DNA binding
  • drug binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
  • zinc ion binding
  • retinoid X receptor binding
  • prostaglandin receptor activity
Processes
  • innate immune response
  • diet induced thermogenesis
  • negative regulation of sequestering of triglyceride
  • positive regulation of fat cell differentiation
  • lipoprotein transport
  • cellular response to retinoic acid
  • response to cold
  • white fat cell differentiation
  • response to immobilization stress
  • cellular response to vitamin E
  • negative regulation of cell growth
  • positive regulation of oligodendrocyte differentiation
  • positive regulation of transcription, DNA-templated
  • positive regulation of phagocytosis, engulfment
  • response to mechanical stimulus
  • response to nutrient
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • regulation of circadian rhythm
  • negative regulation of collagen biosynthetic process
  • rhythmic process
  • cell maturation
  • response to diuretic
  • heart development
  • organ regeneration
  • negative regulation of pancreatic stellate cell proliferation
  • regulation of blood pressure
  • long-chain fatty acid transport
  • positive regulation of transcription from RNA polymerase II promoter
  • cellular response to prostaglandin E stimulus
  • negative regulation of telomerase activity
  • fatty acid oxidation
  • response to vitamin A
  • lipid metabolic process
  • lipid homeostasis
  • positive regulation of fatty acid oxidation
  • gene expression
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • G-protein coupled receptor signaling pathway
  • regulation of cholesterol transporter activity
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription involved in cell fate commitment
  • cellular response to lithium ion
  • peroxisome proliferator activated receptor signaling pathway
  • response to metformin
  • placenta development
  • response to caffeine
  • cellular response to hyperoxia
  • response to estrogen
  • negative regulation of smooth muscle cell proliferation
  • response to retinoic acid
  • response to starvation
  • negative regulation of transcription from RNA polymerase II promoter
  • response to lipid
  • negative regulation of acute inflammatory response
  • cellular response to insulin stimulus
  • epithelial cell differentiation
  • glucose homeostasis
  • low-density lipoprotein particle receptor biosynthetic process
  • negative regulation of cholesterol storage
  • cell fate commitment
  • negative regulation of transcription, DNA-templated
  • negative regulation of interferon-gamma-mediated signaling pathway
  • signal transduction
  • negative regulation of macrophage derived foam cell differentiation
  • brown fat cell differentiation
  • negative regulation of receptor biosynthetic process
  • response to low-density lipoprotein particle
  • monocyte differentiation
Components
  • nucleus
  • intracellular membrane-bounded organelle
  • Golgi apparatus
  • RNA polymerase II transcription factor complex
  • cytosol
  • nucleoplasm
  • perinuclear region of cytoplasm
General FunctionZinc ion binding
Specific FunctionNuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1711117
UniProtKB IDP37231
UniProtKB Entry NamePPARG_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021642|Peroxisome proliferator-activated receptor gamma (PPARG)
ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTG
GATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTT
GACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA
GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTG
GAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAA
GAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA
TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGGGTTTCTTCCGGAGAACAATCAGA
TTGAAGCTTATCTATGACAGATGTGATCTTAACTGTCGGATCCACAAAAAAAGTAGAAAT
AAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCAGTGGGGATGTCTCATAATGCCATC
AGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAGCTGTTGGCGGAGATCTCCAGTGAT
ATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGGGCCCTGGCAAAACATTTGTATGAC
TCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAGGCGAGGGCGATCTTGACAGGAAAG
ACAACAGACAAATCACCATTCGTTATCTATGACATGAATTCCTTAATGATGGGAGAAGAT
AAAATCAAGTTCAAACACATCACCCCCCTGCAGGAGCAGAGCAAAGAGGTGGCCATCCGC
ATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCTGTGCAGGAGATCACAGAGTATGCC
AAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAACGACCAAGTAACTCTCCTCAAATAT
GGAGTCCACGAGATCATTTACACAATGCTGGCCTCCTTGATGAATAAAGATGGGGTTCTC
ATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTTCTAAAGAGCCTGCGAAAGCCTTTT
GGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTGAAGTTCAATGCACTGGAATTAGAT
GACAGCGACTTGGCAATATTTATTGCTGTCATTATTCTCAGTGGAGACCGCCCAGGTTTG
CTGAATGTGAAGCCCATTGAAGACATTCAAGACAACCTGCTACAAGCCCTGGAGCTCCAG
CTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTTGCCAAGCTGCTCCAGAAAATGACA
GACCTCAGACAGATTGTCACGGAACACGTGCAGCTACTGCAGGTGATCAAGAAGACGGAG
ACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATCTACAAGGACTTGTACTAG
GenBank Gene IDU79012
GeneCard IDNot Available
GenAtlas IDPPARG
HGNC IDHGNC:9236
Chromosome Location3
Locus3p25
References
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