DNA-directed RNA polymerase II subunit RPB9

NameDNA-directed RNA polymerase II subunit RPB9
Synonyms
  • DNA-directed RNA polymerase II subunit I
  • RNA polymerase II 14.5 kDa subunit
  • RNA polymerase II subunit B9
  • RPB14.5
Gene NamePOLR2I
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019709|DNA-directed RNA polymerase II subunit RPB9
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE
Number of residues125
Molecular Weight14523.1
Theoretical pINot Available
GO Classification
Functions
  • zinc ion binding
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • 7-methylguanosine mRNA capping
  • gene silencing by RNA
  • mRNA splicing, via spliceosome
  • piRNA metabolic process
  • DNA repair
  • positive regulation of viral transcription
  • RNA splicing
  • nucleotide-excision repair
  • transcription elongation from RNA polymerase II promoter
  • transcription from RNA polymerase II promoter
  • maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
  • gene expression
  • transcription initiation from RNA polymerase II promoter
  • somatic stem cell population maintenance
  • transcription-coupled nucleotide-excision repair
  • viral process
Components
  • nucleus
  • DNA-directed RNA polymerase II, core complex
  • nucleolus
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP36954
UniProtKB Entry NameRPB9_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019710|DNA-directed RNA polymerase II subunit RPB9 (POLR2I)
ATGGAGCCCGACGGGACTTACGAGCCGGGCTTCGTGGGTATTCGCTTCTGCCAGGAATGT
AACAACATGCTGTACCCCAAGGAAGACAAGGAGAACCGCATTCTGCTCTACGCGTGCCGG
AACTGTGATTACCAGCAGGAGGCCGACAACAGCTGCATCTATGTCAACAAGATCACGCAC
GAAGTGGACGAACTGACCCAGATTATCGCCGACGTGTCCCAGGACCCCACGTTGCCGCGG
ACCGAGGACCACCCGTGCCAAAAGTGCGGCCACAAGGAGGCTGTGTTCTTCCAGTCACAC
AGTGCGCGGGCCGAGGACGCCATGCGCCTTTACTACGTGTGCACAGCCCCACACTGCGGC
CACCGCTGGACCGAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9196
Chromosome Location19
LocusNot Available
References
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