NameNeuronal acetylcholine receptor subunit alpha-7
Synonyms
  • NACHRA7
Gene NameCHRNA7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004597|Neuronal acetylcholine receptor subunit alpha-7
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
Number of residues502
Molecular Weight56448.925
Theoretical pI6.44
GO Classification
Functions
  • acetylcholine-gated cation channel activity
  • protein homodimerization activity
  • acetylcholine-activated cation-selective channel activity
  • chloride channel regulator activity
  • beta-amyloid binding
  • toxic substance binding
  • acetylcholine binding
  • drug binding
  • acetylcholine receptor activity
Processes
  • negative regulation of tumor necrosis factor production
  • calcium ion transport
  • activation of MAPK activity
  • B cell activation
  • signal transduction
  • T cell activation
  • behavioral response to nicotine
  • response to nicotine
  • cognition
  • regulation of synaptic transmission, dopaminergic
  • regulation of membrane potential
  • negative regulation of inflammatory response
  • synaptic transmission
  • negative regulation of interleukin-6 production
  • endocytosis
  • response to food
  • cation transmembrane transport
  • associative learning
  • behavioral response to ethanol
  • cellular calcium ion homeostasis
  • generation of ovulation cycle rhythm
  • sperm motility
  • regulation of norepinephrine secretion
  • ion transmembrane transport
  • response to hypoxia
  • neuronal action potential
  • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
  • dopamine biosynthetic process
  • memory
  • synaptic transmission, cholinergic
  • positive regulation of cell proliferation
  • negative regulation of interleukin-1 beta production
  • ion transport
  • positive regulation of angiogenesis
Components
  • membrane raft
  • neuron projection
  • postsynaptic density
  • postsynaptic membrane
  • plasma membrane
  • axolemma
  • apical plasma membrane
  • cell junction
  • dendritic spine
  • dendritic shaft
  • integral component of membrane
  • external side of plasma membrane
  • acetylcholine-gated channel complex
  • growth cone
  • asymmetric synapse
  • synapse
  • neuronal cell body
  • cytoplasm
  • presynaptic membrane
General FunctionToxic substance binding
Specific FunctionAfter binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Pfam Domain Function
Transmembrane Regions231-255 262-280 296-317 470-490
GenBank Protein ID496607
UniProtKB IDP36544
UniProtKB Entry NameACHA7_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0020606|Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)
ATGCGCTGCTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCC
CTGCAAGGCGAGTTCCAGAGGAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTG
GAGAGGCCCGTGGCCAATGACTCGCAACCACTCACCGTCTACTTCTCCCTGAGCCTCCTG
CAGATCATGGACGTGGATGAGAAGAACCAAGTTTTAACCACCAACATTTGGCTGCAAATG
TCTTGGACAGATCACTATTTACAGTGGAATGTGTCAGAATATCCAGGGGTGAAGACTGTT
CGTTTCCCAGATGGCCAGATTTGGAAACCAGACATTCTTCTCTATAACAGTGCTGATGAG
CGCTTTGACGCCACATTCCACACTAACGTGTTGGTGAATTCTTCTGGGCATTGCCAGTAC
CTGCCTCCAGGCATATTCAAGAGTTCCTGCTACATCGATGTACGCTGGTTTCCCTTTGAT
GTGCAGCACTGCAAACTGAAGTTTGGGTCCTGGTCTTACGGAGGCTGGTCCTTGGATCTG
CAGATGCAGGAGGCAGATATCAGTGGCTATATCCCCAATGGAGAATGGGACCTAGTGGGA
ATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAGTGCTGCAAAGAGCCCTACCCCGATGTC
ACCTTCACAGTGACCATGCGCCGCAGGACGCTCTACTATGGCCTCAACCTGCTGATCCCC
TGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCGGGGAG
AAGATTTCCCTGGGGATAACAGTCTTACTCTCTCTTACCGTCTTCATGCTGCTCGTGGCT
GAGATCATGCCCGCAACATCCGATTCGGTACCATTGATAGCCCAGTACTTCGCCAGCACC
ATGATCATCGTGGGCCTCTCGGTGGTGGTGACAGTGATCGTGCTGCAGTACCACCACCAC
GACCCCGACGGGGGCAAGATGCCCAAGTGGACCAGAGTCATCCTTCTGAACTGGTGCGCG
TGGTTCCTGCGAATGAAGAGGCCCGGGGAGGACAAGGTGCGCCCGGCCTGCCAGCACAAG
CAGCGGCGCTGCAGCCTGGCCAGTGTGGAGATGAGCGCCGTGGCGCCGCCGCCCGCCAGC
AACGGGAACCTGCTGTACATCGGCTTCCGCGGCCTGGACGGCGTGCACTGTGTCCCGACC
CCCGACTCTGGGGTAGTGTGTGGCCGCATGGCCTGCTCCCCCACGCACGATGAGCACCTC
CTGCACGGCGGGCAACCCCCCGAGGGGGACCCGGACTTGGCCAAGATCCTGGAGGAGGTC
CGCTACATTGCCAACCGCTTCCGCTGCCAGGACGAAAGCGAGGCGGTCTGCAGCGAGTGG
AAGTTCGCCGCCTGTGTGGTGGACCGCCTGTGCCTCATGGCCTTCTCGGTCTTCACCATC
ATCTGCACCATCGGCATCCTGATGTCGGCTCCCAACTTCGTGGAGGCCGTGTCCAAAGAC
TTTGCGTAA
GenBank Gene IDX70297
GeneCard IDNot Available
GenAtlas IDCHRNA7
HGNC IDHGNC:1960
Chromosome Location15
Locus15q14
References
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  3. Groot Kormelink PJ, Luyten WH: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. FEBS Lett. 1997 Jan 6;400(3):309-14. 9009220
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