Dual specificity mitogen-activated protein kinase kinase 2

NameDual specificity mitogen-activated protein kinase kinase 2
Synonyms
  • 2.7.12.2
  • ERK activator kinase 2
  • MAP kinase kinase 2
  • MAPK/ERK kinase 2
  • MEK 2
  • MEK2
  • MKK2
  • PRKMK2
Gene NameMAP2K2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020804|Dual specificity mitogen-activated protein kinase kinase 2
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
Number of residues400
Molecular Weight44423.735
Theoretical pINot Available
GO Classification
Functions
  • protein serine/threonine kinase activity
  • metal ion binding
  • PDZ domain binding
  • scaffold protein binding
  • protein serine/threonine/tyrosine kinase activity
  • MAP kinase kinase activity
  • protein tyrosine kinase activity
  • protein serine/threonine kinase activator activity
  • ATP binding
Processes
  • activation of MAPKK activity
  • fibroblast growth factor receptor signaling pathway
  • regulation of stress-activated MAPK cascade
  • insulin receptor signaling pathway
  • ERK1 and ERK2 cascade
  • MAPK cascade
  • positive regulation of cell motility
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of protein serine/threonine kinase activity
  • Ras protein signal transduction
  • small GTPase mediated signal transduction
  • regulation of early endosome to late endosome transport
  • vascular endothelial growth factor receptor signaling pathway
  • regulation of Golgi inheritance
  • trachea formation
  • activation of MAPK activity
  • peptidyl-serine autophosphorylation
  • axon guidance
  • regulation of axon regeneration
  • negative regulation of gene expression
  • epidermal growth factor receptor signaling pathway
  • positive regulation of axonogenesis
  • innate immune response
  • epithelial cell proliferation involved in lung morphogenesis
  • Fc-epsilon receptor signaling pathway
Components
  • cytoplasmic side of plasma membrane
  • microtubule
  • extracellular region
  • nucleus
  • endoplasmic reticulum
  • Golgi apparatus
  • cytosol
  • focal adhesion
  • perinuclear region of cytoplasm
  • cell-cell junction
  • cytoplasm
  • late endosome
  • mitochondrion
  • early endosome
  • cell cortex
  • peroxisomal membrane
General FunctionScaffold protein binding
Specific FunctionCatalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP36507
UniProtKB Entry NameMP2K2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020805|Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)
ATGCTGGCCCGGAGGAAGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAG
GGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGGACCTGCAGAAGAAG
CTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAG
AAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCG
GGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCCTCATCATGGCCAGG
AAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAG
GTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGAC
GGGGAGATCAGCATTTGCATGGAACACATGGACGGCGGCTCCCTGGACCAGGTGCTGAAA
GAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGGGGC
TTGGCGTACCTCCGAGAGAAGCACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATC
CTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGCCAGCTCATC
GACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAG
GGCACACATTACTCGGTGCAGTCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTG
GCCGTCGGAAGGTACCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCCATCTTTGGC
CGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGGCCC
CCCGGGCGCCCCGTCAGCGGTCACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAA
CTCCTGGACTATATTGTGAACGAGCCACCTCCTAAGCTGCCCAACGGTGTGTTCACCCCC
GACTTCCAGGAGTTTGTCAATAAATGCCTCATCAAGAACCCAGCGGAGCGGGCGGACCTG
AAGATGCTCACAAACCACACCTTCATCAAGCGGTCCGAGGTGGAAGAAGTGGATTTTGCC
GGCTGGTTGTGTAAAACCCTGCGGCTGAACCAGCCCGGCACACCCACGCGCACCGCCGTG
TGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6842
Chromosome Location19
LocusNot Available
References
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