NameProtein phosphatase 1A
Synonyms
  • 3.1.3.16
  • PP2C-alpha
  • PPPM1A
  • Protein phosphatase 2C isoform alpha
  • Protein phosphatase IA
Gene NamePPM1A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009180|Protein phosphatase 1A
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA
VYNRLNPYKNDDTDSTSTDDMW
Number of residues382
Molecular Weight42447.455
Theoretical pINot Available
GO Classification
Functions
  • manganese ion binding
  • magnesium ion binding
  • R-SMAD binding
  • protein serine/threonine phosphatase activity
  • calmodulin-dependent protein phosphatase activity
  • signal transducer activity
Processes
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of Wnt signaling pathway
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • N-terminal protein myristoylation
  • gene expression
  • positive regulation of protein export from nucleus
  • transcription initiation from RNA polymerase II promoter
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • positive regulation of transcription, DNA-templated
  • negative regulation of NF-kappaB import into nucleus
  • insulin receptor signaling pathway
  • negative regulation of BMP signaling pathway
  • peptidyl-threonine dephosphorylation
  • negative regulation of transcription from RNA polymerase II promoter
  • transcription, DNA-templated
  • negative regulation of SMAD protein complex assembly
  • transforming growth factor beta receptor signaling pathway
  • protein dephosphorylation
  • dephosphorylation
  • Wnt signaling pathway
  • cell cycle arrest
Components
  • cytosol
  • nucleoplasm
  • neuron projection
  • membrane
  • voltage-gated calcium channel complex
  • nucleus
General FunctionSignal transducer activity
Specific FunctionEnzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP35813
UniProtKB Entry NamePPM1A_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017713|Protein phosphatase 1A (PPM1A)
ATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAAT
GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACAT
ACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGAT
GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC
AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA
ATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACAT
GGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTAT
TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTC
ACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGC
TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTT
GATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAA
GTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGT
ATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC
ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT
CGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA
GCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATA
AAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG
AACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCC
GTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGAT
ATGTGGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9275
Chromosome Location14
LocusNot Available
References
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