NameD(3) dopamine receptor
Synonyms
  • Dopamine D3 receptor
Gene NameDRD3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001159|D(3) dopamine receptor
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Number of residues400
Molecular Weight44224.335
Theoretical pI9.07
GO Classification
Functions
  • drug binding
  • G-protein coupled amine receptor activity
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go
  • dopamine binding
Processes
  • musculoskeletal movement, spinal reflex action
  • regulation of circadian sleep/wake cycle, sleep
  • regulation of cAMP metabolic process
  • response to drug
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • positive regulation of dopamine receptor signaling pathway
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway
  • cellular calcium ion homeostasis
  • regulation of dopamine uptake involved in synaptic transmission
  • synaptic transmission
  • arachidonic acid secretion
  • learning
  • gastric emptying
  • negative regulation of protein secretion
  • negative regulation of blood pressure
  • response to cocaine
  • negative regulation of dopamine receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • response to histamine
  • synaptic transmission, dopaminergic
  • negative regulation of sodium
  • G-protein coupled receptor signaling pathway
  • positive regulation of cytokinesis
  • negative regulation of adenylate cyclase activity
  • sensory perception of chemical stimulus
  • learning or memory
  • positive regulation of renal sodium excretion
  • regulation of blood volume by renin-angiotensin
  • positive regulation of cell proliferation
  • prepulse inhibition
  • social behavior
  • regulation of locomotion involved in locomotory behavior
  • dopamine metabolic process
  • regulation of dopamine secretion
  • positive regulation of mitotic nuclear division
  • locomotory behavior
  • circadian regulation of gene expression
  • response to amphetamine
  • negative regulation of oligodendrocyte differentiation
  • negative regulation of transcription from RNA polymerase II promoter
  • G-protein coupled receptor internalization
  • visual learning
  • regulation of lipid metabolic process
  • response to morphine
  • regulation of multicellular organism growth
  • negative regulation of protein kinase B signaling
  • behavioral response to cocaine
  • acid secretion
Components
  • plasma membrane
  • integral component of plasma membrane
  • apical part of cell
  • cell projection
  • endocytic vesicle
General FunctionG-protein coupled amine receptor activity
Specific FunctionDopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Pfam Domain Function
Transmembrane Regions33-55 66-88 105-126 150-170 188-212 330-351 367-388
GenBank Protein ID927342
UniProtKB IDP35462
UniProtKB Entry NameDRD3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021269|D(3) dopamine receptor (DRD3)
ATGGCATCTCTGAGCCAGCTGAGTGGCCACCTGAACTACACCTGTGGGGCAGAGAACTCC
ACAGGTGCCAGCCAGGCCCGCCCACATGCCTACTATGCCCTCTCCTACTGCGCGCTCATC
CTGGCCATCGTCTTCGGCAATGGCCTGGTGTGCATGGCTGTGCTGAAGGAGCGGGCCCTG
CAGACTACCACCAACTACTTAGTAGTGAGCCTGGCTGTGGCAGACTTGCTGGTGGCCACC
TTGGTGATGCCCTGGGTGGTATACCTGGAGGTGACAGGTGGAGTCTGGAATTTCAGCCGC
ATTTGCTGTGATGTTTTTGTCACCCTGGATGTCATGATGTGTACAGCCAGCATCCTTAAT
CTCTGTGCCATCAGCATAGACAGGTACACTGCAGTGGTCATGCCCGTTCACTACCAGCAT
GGCACGGGACAGAGCTCCTGTCGGCGCGTGGCCCTCATGATCACGGCCGTCTGGGTACTG
GCCTTTGCTGTGTCCTGCCCTCTTCTGTTTGGCTTTAATACCACAGGGGACCCCACTGTC
TGCTCCATCTCCAACCCTGATTTTGTCATCTACTCTTCAGTGGTGTCCTTCTACCTGCCC
TTTGGAGTGACTGTCCTTGTCTATGCCAGAATCTATGTGGTGCTGAAACAAAGGAGACGG
AAAAGGATCCTCACTCGACAGAACAGTCAGTGCAACAGTGTCAGGCCTGGCTTCCCCCAA
CAAACCCTCTCTCCTGACCCGGCACATCTGGAGCTGAAGCGTTACTACAGCATCTGCCAG
GACACTGCCTTGGGTGGACCAGGCTTCCAAGAAAGAGGAGGAGAGTTGAAAAGAGAGGAG
AAGACTCGGAATTCCCTGAGTCCCACCATAGCGCCCAAGCTCAGCTTAGAAGTTCGAAAA
CTCAGCAATGGCAGATTATCGACATCTTTGAAGCTGGGGCCCCTGCAACCTCGGGGAGTG
CCACTTCGGGAGAAGAAGGCAACCCAAATGGTGGCCATTGTGCTTGGGGCCTTCATTGTC
TGCTGGCTGCCCTTCTTCTTGACCCATGTTCTCAATACCCACTGCCAGACATGCCACGTG
TCCCCAGAGCTTTACAGTGCCACGACATGGCTGGGCTACGTGAATAGCGCCCTCAACCCT
GTGATCTATACCACCTTCAATATCGAGTTCCGGAAAGCCTTCCTCAAGATCCTGTCTTGC
TGA
GenBank Gene IDU32499
GeneCard IDNot Available
GenAtlas IDDRD3
HGNC IDHGNC:3024
Chromosome Location3
Locus3q13.3
References
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