Prostaglandin G/H synthase 2

NameProstaglandin G/H synthase 2
Synonyms
  • 1.14.99.1
  • COX-2
  • COX2
  • Cyclooxygenase-2
  • PGH synthase 2
  • PGHS-2
  • PHS II
  • Prostaglandin H2 synthase 2
  • Prostaglandin-endoperoxide synthase 2
Gene NamePTGS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021832|Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
Number of residues604
Molecular Weight68995.625
Theoretical pI7.41
GO Classification
Functions
  • lipid binding
  • metal ion binding
  • arachidonate 15-lipoxygenase activity
  • enzyme binding
  • heme binding
  • prostaglandin-endoperoxide synthase activity
  • peroxidase activity
Processes
  • negative regulation of cell cycle
  • response to drug
  • cellular response to fluid shear stress
  • positive regulation of vascular endothelial growth factor production
  • vitamin metabolic process
  • positive regulation of fibroblast growth factor production
  • positive regulation of NF-kappaB import into nucleus
  • arachidonic acid metabolic process
  • water-soluble vitamin metabolic process
  • positive regulation of platelet-derived growth factor production
  • response to oxidative stress
  • response to tumor necrosis factor
  • lipoxygenase pathway
  • response to glucocorticoid
  • positive regulation of transforming growth factor beta production
  • regulation of blood pressure
  • response to lipopolysaccharide
  • inflammatory response
  • nicotinamide metabolic process
  • response to manganese ion
  • sensory perception of pain
  • prostaglandin biosynthetic process
  • positive regulation of cell migration involved in sprouting angiogenesis
  • bone mineralization
  • cellular response to ATP
  • small molecule metabolic process
  • response to fructose
  • embryo implantation
  • angiogenesis
  • positive regulation of apoptotic process
  • cellular response to UV
  • response to lithium ion
  • movement of cell or subcellular component
  • negative regulation of smooth muscle contraction
  • response to fatty acid
  • learning
  • cellular response to mechanical stimulus
  • positive regulation of fever generation
  • positive regulation of prostaglandin biosynthetic process
  • response to estradiol
  • positive regulation of brown fat cell differentiation
  • brown fat cell differentiation
  • ovulation
  • positive regulation of vasoconstriction
  • negative regulation of cell proliferation
  • maintenance of blood-brain barrier
  • negative regulation of calcium ion transport
  • prostaglandin metabolic process
  • positive regulation of smooth muscle cell proliferation
  • positive regulation of smooth muscle contraction
  • positive regulation of synaptic plasticity
  • response to vitamin D
  • positive regulation of nitric oxide biosynthetic process
  • cellular response to hypoxia
  • regulation of inflammatory response
  • negative regulation of synaptic transmission, dopaminergic
  • decidualization
  • positive regulation of synaptic transmission, glutamatergic
  • memory
  • NAD metabolic process
  • hair cycle
  • cyclooxygenase pathway
Components
  • neuron projection
  • endoplasmic reticulum membrane
  • caveola
  • endoplasmic reticulum lumen
  • cytoplasm
  • protein complex
  • nucleus
  • endoplasmic reticulum
General FunctionProstaglandin-endoperoxide synthase activity
Specific FunctionConverts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID291988
UniProtKB IDP35354
UniProtKB Entry NamePGH2_HUMAN
Cellular LocationMicrosome membrane
Gene sequence
>lcl|BSEQ0021833|Prostaglandin G/H synthase 2 (PTGS2)
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
GenBank Gene IDL15326
GeneCard IDNot Available
GenAtlas IDPTGS2
HGNC IDHGNC:9605
Chromosome Location1
Locus1q25.2-q25.3
References
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