Prostaglandin G/H synthase 2

NameProstaglandin G/H synthase 2
Synonyms
  • 1.14.99.1
  • COX-2
  • COX2
  • Cyclooxygenase-2
  • PGH synthase 2
  • PGHS-2
  • PHS II
  • Prostaglandin H2 synthase 2
  • Prostaglandin-endoperoxide synthase 2
Gene NamePTGS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021832|Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
Number of residues604
Molecular Weight68995.625
Theoretical pI7.41
GO Classification
Functions
  • prostaglandin-endoperoxide synthase activity
  • lipid binding
  • arachidonate 15-lipoxygenase activity
  • metal ion binding
  • enzyme binding
  • heme binding
  • peroxidase activity
Processes
  • NAD metabolic process
  • cyclooxygenase pathway
  • memory
  • negative regulation of smooth muscle contraction
  • vitamin metabolic process
  • negative regulation of cell cycle
  • response to drug
  • positive regulation of vascular endothelial growth factor production
  • positive regulation of brown fat cell differentiation
  • water-soluble vitamin metabolic process
  • arachidonic acid metabolic process
  • maintenance of blood-brain barrier
  • ovulation
  • response to oxidative stress
  • lipoxygenase pathway
  • regulation of blood pressure
  • positive regulation of synaptic plasticity
  • response to glucocorticoid
  • prostaglandin metabolic process
  • response to manganese ion
  • negative regulation of synaptic transmission, dopaminergic
  • response to lipopolysaccharide
  • positive regulation of nitric oxide biosynthetic process
  • inflammatory response
  • hair cycle
  • sensory perception of pain
  • positive regulation of synaptic transmission, glutamatergic
  • bone mineralization
  • positive regulation of fibroblast growth factor production
  • cellular response to fluid shear stress
  • small molecule metabolic process
  • embryo implantation
  • positive regulation of platelet-derived growth factor production
  • cellular response to ATP
  • positive regulation of NF-kappaB import into nucleus
  • positive regulation of apoptotic process
  • response to lithium ion
  • angiogenesis
  • response to tumor necrosis factor
  • response to fatty acid
  • movement of cell or subcellular component
  • positive regulation of transforming growth factor beta production
  • cellular response to mechanical stimulus
  • positive regulation of fever generation
  • learning
  • nicotinamide metabolic process
  • response to estradiol
  • brown fat cell differentiation
  • positive regulation of prostaglandin biosynthetic process
  • prostaglandin biosynthetic process
  • negative regulation of cell proliferation
  • negative regulation of calcium ion transport
  • positive regulation of vasoconstriction
  • positive regulation of cell migration involved in sprouting angiogenesis
  • positive regulation of smooth muscle contraction
  • response to vitamin D
  • positive regulation of smooth muscle cell proliferation
  • response to fructose
  • regulation of inflammatory response
  • decidualization
  • cellular response to hypoxia
  • cellular response to UV
Components
  • endoplasmic reticulum
  • neuron projection
  • endoplasmic reticulum membrane
  • caveola
  • endoplasmic reticulum lumen
  • cytoplasm
  • protein complex
  • nucleus
General FunctionProstaglandin-endoperoxide synthase activity
Specific FunctionConverts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID291988
UniProtKB IDP35354
UniProtKB Entry NamePGH2_HUMAN
Cellular LocationMicrosome membrane
Gene sequence
>lcl|BSEQ0021833|Prostaglandin G/H synthase 2 (PTGS2)
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
GenBank Gene IDL15326
GeneCard IDNot Available
GenAtlas IDPTGS2
HGNC IDHGNC:9605
Chromosome Location1
Locus1q25.2-q25.3
References
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