Pulmonary surfactant-associated protein D

NamePulmonary surfactant-associated protein D
Synonyms
  • COLEC7
  • Collectin-7
  • Lung surfactant protein D
  • PSP-D
  • PSPD
  • SFTP4
Gene NameSFTPD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010774|Pulmonary surfactant-associated protein D
MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPR
GEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGRE
GPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNT
GAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQH
LQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAAL
QQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKW
NDRACGEKRLVVCEF
Number of residues375
Molecular Weight37728.19
Theoretical pI6.54
GO Classification
Functions
  • carbohydrate binding
Processes
  • macrophage chemotaxis
  • reactive oxygen species metabolic process
  • negative regulation of interleukin-2 biosynthetic process
  • innate immune response
  • surfactant homeostasis
  • receptor-mediated endocytosis
  • regulation of immune response
  • cellular protein metabolic process
  • defense response to bacterium
  • positive regulation of phagocytosis
  • negative regulation of T cell proliferation
  • respiratory gaseous exchange
  • lung alveolus development
  • regulation of cytokine production
Components
  • endoplasmic reticulum membrane
  • clathrin-coated endocytic vesicle
  • lysosome
  • collagen trimer
  • endocytic vesicle
  • proteinaceous extracellular matrix
  • extracellular region
  • extracellular space
General FunctionCarbohydrate binding
Specific FunctionContributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID34767
UniProtKB IDP35247
UniProtKB Entry NameSFTPD_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010775|Pulmonary surfactant-associated protein D (SFTPD)
ATGCTGCTCTTCCTCCTCTCTGCACTGGTCCTGCTCACACAGCCCCTGGGCTACCTGGAA
GCAGAAATGAAGACCTACTCCCACAGAACAATGCCCAGTGCTTGCACCCTGGTCATGTGT
AGCTCAGTGGAGAGTGGCCTGCCTGGTCGCGATGGACGGGATGGGAGAGAGGGCCCTCGG
GGCGAGAAGGGGGACCCAGGTTTGCCAGGAGCTGCAGGGCAAGCAGGGATGCCTGGACAA
GCTGGCCCAGTTGGGCCCAAAGGGGACAATGGCTCTGTTGGAGAACCTGGACCAAAGGGA
GACACTGGGCCAAGTGGACCTCCAGGACCTCCCGGTGTGCCTGGTCCAGCTGGAAGAGAA
GGTCCCCTGGGGAAGCAGGGGAACATAGGACCTCAGGGCAAGCCAGGCCCAAAAGGAGAA
GCTGGGCCCAAAGGAGAAGTAGGTGCCCCAGGCATGCAGGGCTCGGCAGGGGCAAGAGGC
CTCGCAGGCCCTAAGGGAGAGCGAGGTGTCCCTGGTGAGCGTGGAGTCCCTGGAAACACA
GGGGCAGCAGGGTCTGCTGGAGCCATGGGTCCCCAGGGAAGTCCAGGTGCCAGGGGACCC
CCGGGATTGAAGGGGGACAAAGGCATTCCTGGAGACAAAGGAGCAAAGGGAGAAAGTGGG
CTTCCAGATGTTGCTTCTCTGAGGCAGCAGGTTGAGGCCTTACAGGGACAAGTACAGCAC
CTCCAGGCTGCTTTCTCTCAGTATAAGAAAGTTGAGCTCTTCCCAAATGGCCAAAGTGTC
GGGGAGAAGATTTTCAAGACAGCAGGCTTTGTAAAACCATTTACGGAGGCACAGCTGCTG
TGCACACAGGCTGGTGGACAGTTGGCCTCTCCACGCTCTGCCGCTGAGAATGCCGCCTTG
CAACAGCTGGTCGTAGCTAAGAACGAGGCTGCTTTCCTGAGCATGACTGATTCCAAGACA
GAGGGCAAGTTCACCTACCCCACAGGAGAGTCCCTGGTCTATTCCAACTGGGCCCCAGGG
GAGCCCAACGATGATGGCGGGTCAGAGGACTGTGTGGAGATCTTCACCAATGGCAAGTGG
AATGACAGGGCTTGTGGAGAAAAGCGTCTTGTGGTCTGCGAGTTCTGA
GenBank Gene IDX65018
GeneCard IDNot Available
GenAtlas IDSFTPD
HGNC IDHGNC:10803
Chromosome Location10
Locus10q22.2-q23.1
References
  1. Lu J, Willis AC, Reid KB: Purification, characterization and cDNA cloning of human lung surfactant protein D. Biochem J. 1992 Jun 15;284 ( Pt 3):795-802. 1339284
  2. Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L: Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. J Biol Chem. 1993 Feb 5;268(4):2976-83. 8428971
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  5. Crouch E, Persson A, Chang D: Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. Am J Pathol. 1993 Jan;142(1):241-8. 8424457
  6. Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E: Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. Arch Biochem Biophys. 1991 Oct;290(1):116-26. 1898081
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