Tyrosine-protein phosphatase non-receptor type 7

NameTyrosine-protein phosphatase non-receptor type 7
Synonyms
  • 3.1.3.48
  • Hematopoietic protein-tyrosine phosphatase
  • HEPTP
  • Protein-tyrosine phosphatase LC-PTP
Gene NamePTPN7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008992|Tyrosine-protein phosphatase non-receptor type 7
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEP
ICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHA
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFW
EMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQY
QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGC
FIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
Number of residues360
Molecular Weight40528.965
Theoretical pINot Available
GO Classification
Functions
  • protein tyrosine phosphatase activity
Processes
  • peptidyl-tyrosine dephosphorylation
  • protein dephosphorylation
Components
  • cytoplasm
  • cytoskeleton
  • cytosol
  • cytoplasmic side of plasma membrane
General FunctionProtein tyrosine phosphatase activity
Specific FunctionProtein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP35236
UniProtKB Entry NamePTN7_HUMAN
Cellular LocationCytoplasm
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9659
Chromosome LocationNot Available
LocusNot Available
References
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  2. Zanke B, Suzuki H, Kishihara K, Mizzen L, Minden M, Pawson A, Mak TW: Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase). Eur J Immunol. 1992 Jan;22(1):235-9. 1530918
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