Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Name | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA |
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Synonyms |
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Gene Name | MAN1A1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009460|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIF FLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDN LARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGAT IVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEI FRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHL SHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLL KAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGG MFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEK YYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDD VQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE |
Number of residues | 653 |
Molecular Weight | 72967.88 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
Specific Function | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). |
Pfam Domain Function |
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Transmembrane Regions | 42-62 |
GenBank Protein ID | Not Available |
UniProtKB ID | P33908 |
UniProtKB Entry Name | MA1A1_HUMAN |
Cellular Location | Golgi apparatus membrane |
Gene sequence | >lcl|BSEQ0013174|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) ATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGG GGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAG AAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTC TTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTG CAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGG CGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAAC TTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAG AAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGAGAAGAAGAAGGTGGCCCAGGAC CAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATC GGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAA GAGATGATGAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTAAATGAACTC AAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACT ATAGTAGATGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCA AAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCTGTCTTTGAA GTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGATT TTTCGAAAGAAAGCAGTGGAACTTGGGGTAAAATTGCTACCTGCATTTCATACTCCCTCT GGAATACCTTGGGCATTGCTGAATATGAAAAGTGGTATTGGAAGGAACTGGCCCTGGGCC TCTGGAGGCAGCAGTATTCTGGCAGAATTTGGAACCCTGCATTTGGAGTTTATGCACTTG AGCCACTTATCAGGAAACCCCATCTTTGCTGAAAAGGTAATGAATATTCGAACAGTACTG AACAAACTGGAAAAACCACAAGGCCTTTATCCTAACTATCTGAATCCCAGTAGTGGACAG TGGGGTCAACATCATGTATCAGTTGGAGGACTTGGAGACAGCTTCTATGAGTATTTGCTG AAGGCCTGGTTAATGTCTGACAAGACAGATCTGGAAGCTAAGAAGATGTATTTTGATGCT GTTCAGGCTATCGAGACTCATTTGATCCGCAAGTCTAGCAGCGGACTAACTTATATCGCA GAGTGGAAAGGGGGCCTCCTGGAGCACAAGATGGGCCACCTGACCTGCTTCGCGGGGGGC ATGTTCGCACTCGGGGCTGATGCAGCTCCCGAAGGCATGGCCCAACACTACCTTGAACTC GGGGCTGAAATTGCCCGTACTTGTCATGAATCATATAATCGAACATTTATGAAACTGGGA CCAGAAGCTTTCAGATTTGATGGTGGTGTTGAAGCCATCGCTACAAGACAAAATGAAAAA TACTACATCTTACGGCCAGAAGTTATGGAGACTTACATGTATATGTGGAGACTGACTCAT GATCCAAAGTACAGGAAATGGGCCTGGGAAGCCGTAGAGGCCTTGGAAAACCATTGCAGA GTGAATGGAGGCTATTCAGGCCTAAGGGATGTTTACCTTCTTCATGAGAGTTATGATGAT GTGCAGCAGAGTTTCTTCCTGGCAGAGACATTGAAATATTTGTACCTAATATTTTCTGAC GACGATCTTCTTCCACTGGAGCATTGGATCTTCAATAGCGAGGCACATCTTCTCCCTATC CTCCCTAAAGATAAAAAGGAAGTTGAAATCAGAGAGGAATAA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:6821 |
Chromosome Location | 6 |
Locus | Not Available |
References |
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