T3DB: Kinesin-1 heavy chain

Name	Kinesin-1 heavy chain
Synonyms	Conventional kinesin heavy chain KNS KNS1 Ubiquitous kinesin heavy chain UKHC
Gene Name	KIF5B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0012167\|Kinesin-1 heavy chain MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG KQV
Number of residues	963
Molecular Weight	109684.15
Theoretical pI	6.46
GO Classification	Functions ATP binding microtubule binding microtubule motor activity ATP-dependent microtubule motor activity, plus-end-directed Processes regulation of membrane potential positive regulation of potassium ion transport protein localization positive regulation of synaptic transmission, GABAergic microtubule-based movement cytoplasm organization plus-end-directed vesicle transport along microtubule axon guidance positive regulation of establishment of protein localization to plasma membrane stress granule disassembly cellular protein metabolic process vesicle transport along microtubule cytoskeleton-dependent intracellular transport Components cytoplasm membrane microtubule organizing center microtubule ciliary rootlet kinesin complex vesicle perinuclear region of cytoplasm neuron projection endocytic vesicle
General Function	Microtubule motor activity
Specific Function	Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P33176
UniProtKB Entry Name	KINH_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0012168\|Kinesin-1 heavy chain (KIF5B) ATGGCGGACCTGGCCGAGTGCAACATCAAAGTGATGTGTCGCTTCAGACCTCTCAACGAG TCTGAAGTGAACCGCGGCGACAAGTACATCGCCAAGTTTCAGGGAGAAGACACGGTCGTG ATCGCGTCCAAGCCTTATGCATTTGATCGGGTGTTCCAGTCAAGCACATCTCAAGAGCAA GTGTATAATGACTGTGCAAAGAAGATTGTTAAAGATGTACTTGAAGGATATAATGGAACA ATATTTGCATATGGACAAACATCCTCTGGGAAGACACACACAATGGAGGGTAAACTTCAT GATCCAGAAGGCATGGGAATTATTCCAAGAATAGTGCAAGATATTTTTAATTATATTTAC TCCATGGATGAAAATTTGGAATTTCATATTAAGGTTTCATATTTTGAAATATATTTGGAT AAGATAAGGGACCTGTTAGATGTTTCAAAGACCAACCTTTCAGTTCATGAAGACAAAAAC CGAGTTCCCTATGTAAAGGGGTGCACAGAGCGTTTTGTATGTAGTCCAGATGAAGTTATG GATACCATAGATGAAGGAAAATCCAACAGACATGTAGCAGTTACAAATATGAATGAACAT AGCTCTAGGAGTCACAGTATATTTCTTATTAATGTCAAACAAGAGAACACACAAACGGAA CAAAAGCTGAGTGGAAAACTTTATCTGGTTGATTTAGCTGGTAGTGAAAAGGTTAGTAAA ACTGGAGCTGAAGGTGCTGTGCTGGATGAAGCTAAAAACATCAACAAGTCACTTTCTGCT CTTGGAAATGTTATTTCTGCTTTGGCTGAGGGTAGTACATATGTTCCATATCGAGATAGT AAAATGACAAGAATCCTTCAAGATTCATTAGGTGGCAACTGTAGAACCACTATTGTAATT TGCTGCTCTCCATCATCATACAATGAGTCTGAAACAAAATCTACACTCTTATTTGGCCAA AGGGCCAAAACAATTAAGAACACAGTTTGTGTCAATGTGGAGTTAACTGCAGAACAGTGG AAAAAGAAGTATGAAAAAGAAAAAGAAAAAAATAAGATCCTGCGGAACACTATTCAGTGG CTTGAAAATGAGCTCAACAGATGGCGTAATGGGGAGACGGTGCCTATTGATGAACAGTTT GACAAAGAGAAAGCCAACTTGGAAGCTTTCACAGTGGATAAAGATATTACTCTTACCAAT GATAAACCAGCAACCGCAATTGGAGTTATAGGAAATTTTACTGATGCTGAAAGAAGAAAG TGTGAAGAAGAAATTGCTAAATTATACAAACAGCTTGATGACAAGGATGAAGAAATTAAC CAGCAAAGTCAACTGGTAGAGAAACTGAAGACGCAAATGTTGGATCAGGAGGAGCTTTTG GCATCTACCAGAAGGGATCAAGACAATATGCAAGCTGAGCTGAATCGCCTTCAAGCAGAA AATGATGCCTCTAAAGAAGAAGTGAAAGAAGTTTTACAGGCCCTAGAAGAACTTGCTGTC AATTATGATCAGAAGTCTCAGGAAGTTGAAGACAAAACTAAGGAATATGAATTGCTTAGT GATGAATTGAATCAGAAATCGGCAACTTTAGCGAGTATAGATGCTGAGCTTCAGAAACTT AAGGAAATGACCAACCACCAGAAAAAACGAGCAGCTGAGATGATGGCATCTTTACTAAAA GACCTTGCAGAAATAGGAATTGCTGTGGGAAATAATGATGTAAAGCAGCCTGAGGGAACT GGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGAAGTCAGAA GTAAAAACCATGGTGAAACGTTGCAAGCAGTTAGAAAGCACACAAACTGAGAGCAACAAA AAAATGGAAGAAAATGAAAAGGAGTTAGCAGCATGTCAGCTTCGTATCTCTCAACATGAA GCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAAGACAGTTG GAGGAATCTGTCGATGCCCTCAGTGAAGAACTAGTCCAGCTTCGAGCACAAGAGAAAGTC CATGAAATGGAAAAGGAGCACTTAAATAAGGTTCAGACTGCAAATGAAGTTAAGCAAGCT GTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTAGTTTGAGA GATGAAGTAGAAGCAAAAGCAAAACTTATTACTGATCTTCAAGACCAAAACCAGAAAATG ATGTTAGAGCAGGAACGTCTAAGAGTAGAACATGAGAAGTTGAAAGCCACAGATCAGGAA AAGAGCAGAAAACTACATGAACTTACGGTTATGCAAGATAGACGAGAACAAGCAAGACAA GACTTGAAGGGTTTGGAAGAGACAGTGGCAAAAGAACTTCAGACTTTACACAACCTGCGC AAACTCTTTGTTCAGGACCTGGCTACAAGAGTTAAAAAGAGTGCTGAGATTGATTCTGAT GACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATAATCTTGAA CAGCTCACTAAAGTGCACAAACAGTTGGTACGTGATAATGCAGATCTCCGCTGTGAACTT CCTAAGTTGGAAAAGCGACTTCGAGCTACAGCTGAGAGAGTGAAAGCTTTGGAATCAGCA CTGAAAGAAGCTAAAGAAAATGCATCTCGTGATCGCAAACGCTATCAGCAAGAAGTAGAT CGCATAAAGGAAGCAGTCAGGTCAAAGAATATGGCCAGAAGAGGGCATTCTGCACAGATT GCTAAACCTATTCGTCCCGGGCAACATCCAGCAGCTTCTCCAACTCACCCAAGTGCAATT CGTGGAGGAGGTGCATTTGTTCAGAACAGCCAGCCAGTGGCAGTGCGAGGTGGAGGAGGC AAACAAGTGTAA
GenBank Gene ID	X65873
GeneCard ID	Not Available
GenAtlas ID	KIF5B
HGNC ID	HGNC:6324
Chromosome Location	10
Locus	10pter-q22.1
References	Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD: Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. 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