GTP cyclohydrolase 1

NameGTP cyclohydrolase 1
Synonyms
  • 3.5.4.16
  • DYT5
  • GCH
  • GTP cyclohydrolase I
  • GTP-CH-I
Gene NameGCH1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002101|GTP cyclohydrolase 1
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS
EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA
IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ
VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT
REEFLTLIRS
Number of residues250
Molecular Weight27902.855
Theoretical pI8.82
GO Classification
Functions
  • coenzyme binding
  • zinc ion binding
  • GTP binding
  • calcium ion binding
  • GTP cyclohydrolase I activity
  • protein homodimerization activity
Processes
  • positive regulation of nitric-oxide synthase activity
  • regulation of lung blood pressure
  • protein heterooligomerization
  • regulation of removal of superoxide radicals
  • regulation of blood pressure
  • response to tumor necrosis factor
  • protein homooligomerization
  • response to pain
  • tetrahydrofolate biosynthetic process
  • neuromuscular process controlling posture
  • nitric oxide biosynthetic process
  • nitric oxide metabolic process
  • regulation of nitric-oxide synthase activity
  • small molecule metabolic process
  • response to interferon-gamma
  • tetrahydrobiopterin biosynthetic process
  • dopamine biosynthetic process
  • vasodilation
  • 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
  • response to lipopolysaccharide
  • negative regulation of blood pressure
  • pteridine-containing compound biosynthetic process
Components
  • cytoplasm
  • protein complex
  • nucleus
  • cytoplasmic vesicle
  • cytosol
  • nuclear membrane
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionPositively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID7242659
UniProtKB IDP30793
UniProtKB Entry NameGCH1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010741|GTP cyclohydrolase 1 (GCH1)
ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT
GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG
CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC
GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC
TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG
GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT
ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG
TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG
CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA
GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT
GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA
ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT
CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA
GenBank Gene IDZ29434
GeneCard IDNot Available
GenAtlas IDGCH1
HGNC IDHGNC:4193
Chromosome Location14
Locus14q22.1-q22.2
References
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