Guanine nucleotide-binding protein subunit alpha-15

NameGuanine nucleotide-binding protein subunit alpha-15
Synonyms
  • Epididymis tissue protein Li 17E
  • G alpha-15
  • G alpha-16
  • G-protein subunit alpha-16
  • GNA16
  • Guanine nucleotide-binding protein subunit alpha-16
Gene NameGNA15
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019808|Guanine nucleotide-binding protein subunit alpha-15
MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIK
QMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQD
PYKVTTFEKRYAAAMQWLWRDAGIRAYYERRREFHLLDSAVYYLSHLERITEEGYVPTAQ
DVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQ
CLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQG
PKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVR
DSVLARYLDEINLL
Number of residues374
Molecular Weight43567.615
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • G-protein beta/gamma-subunit complex binding
  • G-protein coupled receptor binding
  • signal transducer activity
  • GTP binding
  • GTPase activity
Processes
  • platelet activation
  • positive regulation of cytosolic calcium ion concentration
  • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
  • phospholipase C-activating dopamine receptor signaling pathway
  • activation of phospholipase C activity
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • blood coagulation
Components
  • plasma membrane
  • heterotrimeric G-protein complex
  • cytosol
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP30679
UniProtKB Entry NameGNA15_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0019809|Guanine nucleotide-binding protein subunit alpha-15 (GNA15)
ATGGCCCGCTCGCTGACCTGGCGCTGCTGCCCCTGGTGCCTGACGGAGGATGAGAAGGCC
GCCGCCCGGGTGGACCAGGAGATCAACAGGATCCTCTTGGAGCAGAAGAAGCAGGACCGC
GGGGAGCTGAAGCTGCTGCTTTTGGGCCCAGGCGAGAGCGGGAAGAGCACCTTCATCAAG
CAGATGCGGATCATCCACGGCGCCGGCTACTCGGAGGAGGAGCGCAAGGGCTTCCGGCCC
CTGGTCTACCAGAACATCTTCGTGTCCATGCGGGCCATGATCGAGGCCATGGAGCGGCTG
CAGATTCCATTCAGCAGGCCCGAGAGCAAGCACCACGCTAGCCTGGTCATGAGCCAGGAC
CCCTATAAAGTGACCACGTTTGAGAAGCGCTACGCTGCGGCCATGCAGTGGCTGTGGAGG
GATGCCGGCATCCGGGCCTGCTATGAGCGTCGGCGGGAATTCCACCTGCTCGATTCAGCC
GTGTACTACCTGTCCCACCTGGAGCGCATCACCGAGGAGGGCTACGTCCCCACAGCTCAG
GACGTGCTCCGCAGCCGCATGCCCACCACTGGCATCAACGAGTACTGCTTCTCCGTGCAG
AAAACCAACCTGCGGATCGTGGACGTCGGGGGCCAGAAGTCAGAGCGTAAGAAATGGATC
CATTGTTTCGAGAACGTGATCGCCCTCATCTACCTGGCCTCACTGAGTGAATACGACCAG
TGCCTGGAGGAGAACAACCAGGAGAACCGCATGAAGGAGAGCCTCGCATTGTTTGGGACT
ATCCTGGAACTACCCTGGTTCAAAAGCACATCCGTCATCCTCTTTCTCAACAAAACCGAC
ATCCTGGAGGAGAAAATCCCCACCTCCCACCTGGCTACCTATTTCCCCAGTTTCCAGGGC
CCTAAGCAGGATGCTGAGGCAGCCAAGAGGTTCATCCTGGACATGTACACGAGGATGTAC
ACCGGGTGCGTGGACGGCCCCGAGGGCAGCAAGAAGGGCGCACGATCCCGACGCCTCTTC
AGCCACTACACATGTGCCACAGACACACAGAACATCCGCAAGGTCTTCAAGGACGTGCGG
GACTCGGTGCTCGCCCGCTACCTGGACGAGATCAACCTGCTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4383
Chromosome Location19
LocusNot Available
References
  1. Amatruda TT 3rd, Steele DA, Slepak VZ, Simon MI: G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5587-91. 1905813
  2. Li J, Liu F, Wang H, Liu X, Liu J, Li N, Wan F, Wang W, Zhang C, Jin S, Liu J, Zhu P, Liu Y: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. Mol Cell Proteomics. 2010 Nov;9(11):2517-28. doi: 10.1074/mcp.M110.001719. Epub 2010 Aug 24. 20736409
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