NameLens fiber major intrinsic protein
Synonyms
  • AQP0
  • Aquaporin-0
  • MIP26
  • MP26
Gene NameMIP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012721|Lens fiber major intrinsic protein
MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG
HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT
LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG
AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA
KPDVSNGQPEVTGEPVELNTQAL
Number of residues263
Molecular Weight28121.5
Theoretical pI8.67
GO Classification
Functions
  • transporter activity
  • structural constituent of eye lens
  • calmodulin binding
  • water channel activity
  • glycerol channel activity
Processes
  • response to stimulus
  • cellular water homeostasis
  • glycerol transport
  • visual perception
  • transmembrane transport
  • ion transmembrane transport
  • water transport
  • lens development in camera-type eye
  • canalicular bile acid transport
Components
  • plasma membrane
  • gap junction
  • integral component of plasma membrane
  • intracellular membrane-bounded organelle
  • apical plasma membrane
  • intracellular canaliculus
General FunctionWater channel activity
Specific FunctionWater channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity).
Pfam Domain Function
Transmembrane Regions9-32 39-61 85-107 127-147 160-176 201-219
GenBank Protein ID49902494
UniProtKB IDP30301
UniProtKB Entry NameMIP_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0012722|Lens fiber major intrinsic protein (MIP)
ATGTGGGAACTGCGATCAGCCTCCTTTTGGAGGGCCATATTCGCTGAGTTCTTTGCCACC
CTCTTCTATGTCTTCTTTGGGCTGGGGTCCTCACTGCGCTGGGCTCCTGGACCCCTGCAT
GTTCTGCAGGTGGCTATGGCATTTGGCTTGGCCCTGGCTACACTGGTGCAGTCTGTGGGC
CACATCAGTGGAGCCCACGTCAATCCTGCAGTCACTTTTGCTTTCCTTGTGGGCTCCCAG
ATGTCCCTGCTCCGTGCCTTCTGCTATATGGCAGCCCAGCTCCTGGGAGCTGTGGCTGGG
GCCGCTGTGCTGTATAGCGTTACCCCACCTGCTGTCCGAGGAAACCTAGCACTCAACACG
TTGCACCCTGCGGTGAGCGTGGGCCAGGCAACCACAGTGGAGATCTTCCTGACGCTCCAG
TTCGTGCTCTGCATCTTTGCCACATACGACGAGAGGCGGAATGGCCAACTGGGCTCCGTG
GCCCTGGCCGTTGGCTTCTCCCTTGCCCTGGGGCACCTCTTTGGGATGTATTATACTGGT
GCAGGCATGAATCCTGCCCGCTCCTTTGCTCCTGCCATTCTCACTGGGAACTTCACTAAC
CACTGGGTGTACTGGGTAGGCCCAATCATTGGAGGGGGTCTGGGCAGCCTCCTGTACGAC
TTTCTTCTCTTCCCCCGGCTCAAGAGTATTTCTGAGAGACTGTCTGTCCTCAAGGGTGCC
AAACCCGATGTCTCCAATGGACAACCAGAGGTCACAGGGGAACCTGTTGAACTGAACACC
CAGGCCCTGTAG
GenBank Gene IDBC074913
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:7103
Chromosome Location12
Locus12q13
References
  1. Pisano MM, Chepelinsky AB: Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens. Genomics. 1991 Dec;11(4):981-90. 1840563
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  8. Gu F, Zhai H, Li D, Zhao L, Li C, Huang S, Ma X: A novel mutation in major intrinsic protein of the lens gene (MIP) underlies autosomal dominant cataract in a Chinese family. Mol Vis. 2007 Sep 11;13:1651-6. 17893667
  9. Lin H, Hejtmancik JF, Qi Y: A substitution of arginine to lysine at the COOH-terminus of MIP caused a different binocular phenotype in a congenital cataract family. Mol Vis. 2007 Sep 30;13:1822-7. 17960133
  10. Wang W, Jiang J, Zhu Y, Li J, Jin C, Shentu X, Yao K: A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family. Mol Vis. 2010 Mar 25;16:534-9. 20361015
  11. Wang KJ, Li SS, Yun B, Ma WX, Jiang TG, Zhu SQ: A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family. Mol Vis. 2011 Jan 8;17:70-7. 21245956