Flavin reductase (NADPH)

NameFlavin reductase (NADPH)
Synonyms
  • 1.5.1.30
  • Biliverdin reductase B
  • Biliverdin-IX beta-reductase
  • BVR-B
  • FLR
  • FR
  • GHBP
  • Green heme-binding protein
  • NADPH-dependent diaphorase
  • NADPH-flavin reductase
Gene NameBLVRB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010413|Flavin reductase (NADPH)
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ
Number of residues206
Molecular Weight22119.215
Theoretical pI7.76
GO Classification
Functions
  • biliverdin reductase activity
  • riboflavin reductase (NADPH) activity
Processes
  • small molecule metabolic process
  • porphyrin-containing compound metabolic process
  • heme catabolic process
Components
  • cytoplasm
  • plasma membrane
  • cytosol
  • extracellular exosome
  • nucleoplasm
General FunctionRiboflavin reductase (nadph) activity
Specific FunctionBroad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1384068
UniProtKB IDP30043
UniProtKB Entry NameBLVRB_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010414|Flavin reductase (NADPH) (BLVRB)
ATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCCTG
GCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTG
CCATCAGAGGGGCCCCGGCCGGCCCACGTGGTAGTGGGAGATGTTCTGCAGGCAGCCGAT
GTGGACAAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGAC
CTCAGTCCCACGACAGTGATGTCCGAGGGCGCCCGGAACATTGTGGCAGCCATGAAGGCT
CATGGTGTGGACAAGGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAG
GTGCCCCCACGACTGCAGGCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCGG
GAATCAGGCCTGAAGTACGTGGCTGTGATGCCGCCACACATAGGAGACCAGCCACTAACT
GGGGCGTACACAGTGACCCTGGATGGACGAGGGCCCTCAAGGGTCATCTCCAAACATGAC
CTGGGCCATTTCATGCTGCGCTGCCTCACCACCGATGAGTACGACGGACACAGCACCTAC
CCCTCCCACCAGTACCAGTAG
GenBank Gene IDD26308
GeneCard IDNot Available
GenAtlas IDBLVRB
HGNC IDHGNC:1063
Chromosome Location19
Locus19q13.1-q13.2
References
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