Peroxiredoxin-6

NamePeroxiredoxin-6
Synonyms
  • 1-Cys peroxiredoxin
  • 1-Cys PRX
  • 1.11.1.15
  • 24 kDa protein
  • Acidic calcium-independent phospholipase A2
  • aiPLA2
  • Antioxidant protein 2
  • AOP2
  • KIAA0106
  • Liver 2D page spot 40
  • Non-selenium glutathione peroxidase
  • NSGPx
  • Red blood cells page spot 12
Gene NamePRDX6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019613|Peroxiredoxin-6
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
Number of residues224
Molecular Weight25034.715
Theoretical pINot Available
GO Classification
Functions
  • antioxidant activity
  • phospholipase A2 activity
  • glutathione peroxidase activity
  • ubiquitin protein ligase binding
  • peroxiredoxin activity
Processes
  • response to oxidative stress
  • hydrogen peroxide catabolic process
  • phospholipid catabolic process
  • response to reactive oxygen species
Components
  • membrane
  • extracellular space
  • lysosome
  • cytosol
  • extracellular exosome
  • cytoplasmic membrane-bounded vesicle
  • cytoplasm
General FunctionUbiquitin protein ligase binding
Specific FunctionInvolved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP30041
UniProtKB Entry NamePRDX6_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019614|Peroxiredoxin-6 (PRDX6)
ATGCCCGGAGGTCTGCTTCTCGGGGACGTGGCTCCCAACTTTGAGGCCAATACCACCGTC
GGCCGCATCCGTTTCCACGACTTTCTGGGAGACTCATGGGGCATTCTCTTCTCCCACCCT
CGGGACTTTACCCCAGTGTGCACCACAGAGCTTGGCAGAGCTGCAAAGCTGGCACCAGAA
TTTGCCAAGAGGAATGTTAAGTTGATTGCCCTTTCAATAGACAGTGTTGAGGACCATCTT
GCCTGGAGCAAGGATATCAATGCTTACAATTGTGAAGAGCCCACAGAAAAGTTACCTTTT
CCCATCATCGATGATAGGAATCGGGAGCTTGCCATCCTGTTGGGCATGCTGGATCCAGCA
GAGAAGGATGAAAAGGGCATGCCTGTGACAGCTCGTGTGGTGTTTGTTTTTGGTCCTGAT
AAGAAGCTGAAGCTGTCTATCCTCTACCCAGCTACCACTGGCAGGAACTTTGATGAGATT
CTCAGGGTAGTCATCTCTCTCCAGCTGACAGCAGAAAAAAGGGTTGCCACCCCAGTTGAT
TGGAAGGATGGGGATAGTGTGATGGTCCTTCCAACCATCCCTGAAGAAGAAGCCAAAAAA
CTTTTCCCGAAAGGAGTCTTCACCAAAGAGCTCCCATCTGGCAAGAAATACCTCCGCTAC
ACACCCCAGCCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:16753
Chromosome Location1
LocusNot Available
References
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