Corticosteroid 11-beta-dehydrogenase isozyme 1

NameCorticosteroid 11-beta-dehydrogenase isozyme 1
Synonyms
  • 1.1.1.146
  • 11-beta-HSD1
  • 11-beta-hydroxysteroid dehydrogenase 1
  • 11-DH
  • HSD11
  • HSD11L
  • SDR26C1
  • Short chain dehydrogenase/reductase family 26C member 1
Gene NameHSD11B1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010089|Corticosteroid 11-beta-dehydrogenase isozyme 1
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Number of residues292
Molecular Weight32400.665
Theoretical pI8.77
GO Classification
Functions
  • 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
  • 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Processes
  • small molecule metabolic process
  • lung development
  • steroid metabolic process
  • glucocorticoid biosynthetic process
Components
  • endoplasmic reticulum membrane
  • integral component of membrane
  • membrane
General Function11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
Specific FunctionCatalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Pfam Domain Function
Transmembrane Regions8-24
GenBank Protein ID179475
UniProtKB IDP28845
UniProtKB Entry NameDHI1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0010090|Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)
ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTAC
TATTCTGCAAACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCACA
GGGGCCAGCAAAGGGATCGGAAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCCCAT
GTGGTGGTGACAGCGAGGTCAAAAGAAACTCTACAGAAGGTGGTATCCCACTGCCTGGAG
CTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGGAAGACATGACCTTCGCAGAG
CAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCATTCTCAACCAC
ATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAAAGCATG
GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCTGAAGCAG
AGCAATGGAAGCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATCCAATGGTT
GCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAA
TATTCAGTGTCCAGGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACA
GAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGCAAGCAGCTCCAAAGGAGGAA
TGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGTATTATGACAGC
TCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTGGAATTTCTCTAC
TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG
GenBank Gene IDM76665
GeneCard IDNot Available
GenAtlas IDHSD11B1
HGNC IDHGNC:5208
Chromosome Location1
Locus1q32-q41
References
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