Mitogen-activated protein kinase 1

NameMitogen-activated protein kinase 1
Synonyms
  • 2.7.11.24
  • ERK-2
  • ERK2
  • ERT1
  • Extracellular signal-regulated kinase 2
  • MAP kinase 1
  • MAP kinase 2
  • MAP kinase isoform p42
  • MAPK 2
  • Mitogen-activated protein kinase 2
  • p42-MAPK
  • PRKM1
  • PRKM2
Gene NameMAPK1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001838|Mitogen-activated protein kinase 1
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Number of residues360
Molecular Weight41389.265
Theoretical pI6.99
GO Classification
Functions
  • ATP binding
  • protein serine/threonine kinase activity
  • phosphatase binding
  • RNA polymerase II carboxy-terminal domain kinase activity
  • DNA binding
  • MAP kinase activity
Processes
  • transcription, DNA-templated
  • positive regulation of telomerase activity
  • insulin receptor signaling pathway
  • ERK1 and ERK2 cascade
  • toll-like receptor 5 signaling pathway
  • activation of MAPK activity
  • positive regulation of telomere capping
  • signal transduction
  • MAPK cascade
  • B cell receptor signaling pathway
  • toll-like receptor 9 signaling pathway
  • peptidyl-threonine phosphorylation
  • positive regulation of telomere maintenance via telomerase
  • neurotrophin TRK receptor signaling pathway
  • toll-like receptor signaling pathway
  • T cell receptor signaling pathway
  • regulation of cellular response to heat
  • protein phosphorylation
  • toll-like receptor TLR1
  • axon guidance
  • peptidyl-serine phosphorylation
  • regulation of cytoskeleton organization
  • Ras protein signal transduction
  • toll-like receptor TLR6
  • cellular response to DNA damage stimulus
  • regulation of early endosome to late endosome transport
  • vascular endothelial growth factor receptor signaling pathway
  • caveolin-mediated endocytosis
  • trachea formation
  • TRIF-dependent toll-like receptor signaling pathway
  • epidermal growth factor receptor signaling pathway
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • regulation of Golgi inheritance
  • blood coagulation
  • labyrinthine layer blood vessel development
  • cellular response to granulocyte macrophage colony-stimulating factor stimulus
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • regulation of protein stability
  • positive regulation of cell proliferation
  • cellular response to heat
  • innate immune response
  • regulation of sequence-specific DNA binding transcription factor activity
  • response to estrogen
  • cytosine metabolic process
  • Fc-epsilon receptor signaling pathway
  • response to epidermal growth factor
  • ERBB signaling pathway
  • lung morphogenesis
  • positive regulation of cell migration
  • viral process
  • response to exogenous dsRNA
  • small GTPase mediated signal transduction
  • sensory perception of pain
  • mammary gland epithelial cell proliferation
  • positive regulation of transcription, DNA-templated
  • stress-activated MAPK cascade
  • synaptic transmission
  • MAPK import into nucleus
  • long-term synaptic potentiation
  • toll-like receptor 10 signaling pathway
  • cell cycle
  • negative regulation of cell differentiation
  • response to toxic substance
  • MyD88-dependent toll-like receptor signaling pathway
  • activation of MAPKK activity
  • positive regulation of translation
  • toll-like receptor 2 signaling pathway
  • chemotaxis
  • lipopolysaccharide-mediated signaling pathway
  • MyD88-independent toll-like receptor signaling pathway
  • apoptotic process
  • regulation of stress-activated MAPK cascade
  • toll-like receptor 3 signaling pathway
  • response to stress
  • positive regulation of peptidyl-threonine phosphorylation
  • fibroblast growth factor receptor signaling pathway
  • toll-like receptor 4 signaling pathway
  • platelet activation
Components
  • protein complex
  • Golgi apparatus
  • cytosol
  • extracellular exosome
  • mitotic spindle
  • nucleoplasm
  • cytoskeleton
  • microtubule cytoskeleton
  • late endosome
  • axon
  • nucleus
  • early endosome
  • perikaryon
  • microtubule organizing center
  • caveola
  • pseudopodium
  • cytoplasm
  • focal adhesion
  • mitochondrion
  • dendrite cytoplasm
General FunctionRna polymerase ii carboxy-terminal domain kinase activity
Specific FunctionSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182191
UniProtKB IDP28482
UniProtKB Entry NameMK01_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010648|Mitogen-activated protein kinase 1 (MAPK1)
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG
CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT
GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT
GTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC
CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC
CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC
TGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC
ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG
AATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA
ATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATT
TTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG
AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT
GACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG
GAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT
TAA
GenBank Gene IDM84489
GeneCard IDNot Available
GenAtlas IDMAPK1
HGNC IDHGNC:6871
Chromosome Location22
Locus22q11.2|22q11.21
References
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