5-hydroxytryptamine receptor 2A

Name5-hydroxytryptamine receptor 2A
Synonyms
  • 5-HT-2
  • HTR2
  • Serotonin receptor 2A
Gene NameHTR2A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000899|5-hydroxytryptamine receptor 2A
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Number of residues471
Molecular Weight52602.58
Theoretical pI7.72
GO Classification
Functions
  • serotonin binding
  • drug binding
  • virus receptor activity
  • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
  • serotonin receptor activity
Processes
  • behavioral response to cocaine
  • positive regulation of fat cell differentiation
  • protein localization to cytoskeleton
  • negative regulation of potassium ion transport
  • cellular calcium ion homeostasis
  • regulation of hormone secretion
  • activation of phospholipase C activity
  • response to drug
  • detection of mechanical stimulus involved in sensory perception of pain
  • positive regulation of vasoconstriction
  • cell death
  • phosphatidylinositol 3-kinase signaling
  • positive regulation of MAP kinase activity
  • artery smooth muscle contraction
  • synaptic transmission
  • positive regulation of ERK1 and ERK2 cascade
  • phospholipase C-activating serotonin receptor signaling pathway
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of phosphatidylinositol biosynthetic process
  • memory
  • release of sequestered calcium ion into cytosol
  • aging
  • positive regulation of cell proliferation
  • regulation of behavior
  • detection of temperature stimulus involved in sensory perception of pain
  • negative regulation of synaptic transmission, glutamatergic
  • sleep
  • temperature homeostasis
  • regulation of dopamine secretion
  • serotonin receptor signaling pathway
  • positive regulation of glycolytic process
  • urinary bladder smooth muscle contraction
Components
  • cytoplasmic membrane-bounded vesicle
  • plasma membrane
  • cytosol
  • neuronal cell body
  • integral component of plasma membrane
  • cell body fiber
  • axon
  • dendritic shaft
  • caveola
General FunctionVirus receptor activity
Specific FunctionG-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
Pfam Domain Function
Transmembrane Regions76-99 111-132 149-171 192-215 234-254 325-346 363-384
GenBank Protein ID36431
UniProtKB IDP28223
UniProtKB Entry Name5HT2A_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0020465|5-hydroxytryptamine receptor 2A (HTR2A)
ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA
TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCCGGAGAAGCTAACACTTCT
GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC
CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG
ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT
ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG
TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG
GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC
ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG
ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG
GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT
GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA
CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT
TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT
AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG
GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC
ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC
CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC
ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG
GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG
TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT
AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT
AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA
GenBank Gene IDS42168
GeneCard IDNot Available
GenAtlas IDHTR2A
HGNC IDHGNC:5293
Chromosome Location13
Locus13q14-q21
References
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