Phosphatidylinositol 3-kinase regulatory subunit alpha

NamePhosphatidylinositol 3-kinase regulatory subunit alpha
Synonyms
  • GRB1
  • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
  • PI3-kinase regulatory subunit alpha
  • PI3-kinase subunit p85-alpha
  • PtdIns-3-kinase regulatory subunit p85-alpha
Gene NamePIK3R1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001901|Phosphatidylinositol 3-kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
Number of residues724
Molecular Weight83597.675
Theoretical pI6.06
GO Classification
Functions
  • phosphatidylinositol 3-kinase regulator activity
  • protein phosphatase binding
  • insulin binding
  • neurotrophin TRKA receptor binding
  • 1-phosphatidylinositol-3-kinase regulator activity
  • transcription factor binding
  • ErbB-3 class receptor binding
  • insulin receptor binding
  • insulin receptor substrate binding
  • insulin-like growth factor receptor binding
  • phosphatidylinositol 3-kinase binding
  • transmembrane receptor protein tyrosine kinase adaptor activity
Processes
  • positive regulation of glucose import in response to insulin stimulus
  • T cell receptor signaling pathway
  • positive regulation of transcription factor import into nucleus
  • Fc-epsilon receptor signaling pathway
  • phosphatidylinositol phosphorylation
  • positive regulation of RNA splicing
  • leukocyte migration
  • protein stabilization
  • response to endoplasmic reticulum stress
  • positive regulation of cell migration
  • phosphatidylinositol biosynthetic process
  • negative regulation of cell-matrix adhesion
  • fibroblast growth factor receptor signaling pathway
  • insulin receptor signaling pathway
  • blood coagulation
  • growth hormone receptor signaling pathway
  • NFAT protein import into nucleus
  • negative regulation of apoptotic process
  • insulin-like growth factor receptor signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • viral process
  • positive regulation of transcription from RNA polymerase II promoter
  • protein phosphorylation
  • regulation of phosphatidylinositol 3-kinase activity
  • phosphatidylinositol 3-kinase signaling
  • vascular endothelial growth factor receptor signaling pathway
  • platelet activation
  • B cell differentiation
  • positive regulation of tumor necrosis factor production
  • small molecule metabolic process
  • cellular glucose homeostasis
  • cellular response to insulin stimulus
  • positive regulation of establishment of protein localization to plasma membrane
  • negative regulation of osteoclast differentiation
  • phosphatidylinositol-mediated signaling
  • extrinsic apoptotic signaling pathway via death domain receptors
  • epidermal growth factor receptor signaling pathway
  • phospholipid metabolic process
  • regulation of stress fiber assembly
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • cellular response to UV
  • innate immune response
  • T cell costimulation
  • positive regulation of endoplasmic reticulum unfolded protein response
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • positive regulation of glucose import
Components
  • perinuclear endoplasmic reticulum membrane
  • cytoplasm
  • membrane
  • cis-Golgi network
  • phosphatidylinositol 3-kinase complex
  • nucleus
  • phosphatidylinositol 3-kinase complex, class IA
  • plasma membrane
  • cytosol
  • cell-cell junction
General FunctionTransmembrane receptor protein tyrosine kinase adaptor activity
Specific FunctionBinds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP27986
UniProtKB Entry NameP85A_HUMAN
Cellular LocationCytoplasmic
Gene sequence
>lcl|BSEQ0021657|Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
ATGCATGGTGATTATACTCTTACACTAAGGAAAGGGGGAAATAACAAATTAATCAAAATA
TTTCATCGAGATGGGAAATATGGCTTCTCTGACCCATTAACCTTCAGTTCTGTGGTTGAA
TTAATAAACCACTACCGGAATGAATCTCTAGCTCAGTATAATCCCAAATTGGATGTGAAA
TTACTTTATCCAGTATCCAAATACCAACAGGATCAAGTTGTCAAAGAAGATAATATTGAA
GCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATAT
GATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCT
ATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGG
TACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGG
ATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGA
AGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATG
AACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGG
TTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACT
GAAGACCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACA
TGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGAT
GGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTG
GACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAG
CCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTT
GTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGG
CGATGA
GenBank Gene IDM61906
GeneCard IDNot Available
GenAtlas IDPIK3R1
HGNC IDHGNC:8979
Chromosome Location5
Locus5q13.1
References
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