Serum paraoxonase/arylesterase 1

NameSerum paraoxonase/arylesterase 1
Synonyms
  • 3.1.1.2
  • A-esterase 1
  • Aromatic esterase 1
  • K-45
  • PON
  • PON 1
  • Serum aryldialkylphosphatase 1
Gene NamePON1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020496|Serum paraoxonase/arylesterase 1
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
Number of residues355
Molecular Weight39730.99
Theoretical pI4.89
GO Classification
Functions
  • protein homodimerization activity
  • calcium ion binding
  • aryldialkylphosphatase activity
  • phospholipid binding
  • arylesterase activity
Processes
  • organophosphate catabolic process
  • positive regulation of transporter activity
  • response to fluoride
  • response to nutrient levels
  • response to toxic substance
  • positive regulation of cholesterol efflux
  • response to fatty acid
  • dephosphorylation
  • positive regulation of binding
  • aromatic compound catabolic process
  • phosphatidylcholine metabolic process
  • response to external stimulus
  • carboxylic acid catabolic process
Components
  • intracellular membrane-bounded organelle
  • blood microparticle
  • extracellular region
  • high-density lipoprotein particle
  • spherical high-density lipoprotein particle
  • extracellular space
  • extracellular exosome
General FunctionProtein homodimerization activity
Specific FunctionHydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190192
UniProtKB IDP27169
UniProtKB Entry NamePON1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020497|Serum paraoxonase/arylesterase 1 (PON1)
ATGGCGAAGCTGATTGCGCTCACCCTCTTGGGGATGGGACTGGCACTCTTCAGGAACCAC
CAGTCTTCTTACCAAACACGACTTAATGCTCTCCGAGAGGTACAACCCGTAGAACTTCCT
AACTGTAATTTAGTTAAAGGAATCGAAACTGGCTCTGAAGACTTGGAGATACTGCCTAAT
GGACTGGCTTTCATTAGCTCTGGATTAAAGTATCCTGGAATAAAGAGCTTCAACCCCAAC
AGTCCTGGAAAAATACTTCTGATGGACCTGAATGAAGAAGATCCAACAGTGTTGGAATTG
GGGATCACTGGAAGTAAATTTGATGTATCTTCATTTAACCCTCATGGGATTAGCACATTC
ACAGATGAAGATAATGCCATGTACCTCCTGGTGGTGAACCATCCAGATGCCAAGTCCACA
GTGGAGTTGTTTAAATTTCAAGAAGAAGAAAAATCGCTTTTGCATCTAAAAACCATCAGA
CATAAACTTCTGCCTAATTTGAATGATATTGTTGCTGTGGGACCTGAGCACTTTTATGGC
ACAAATGATCACTATTTTCTTGACCCCTACTTACAATCCTGGGAGATGTATTTGGGTTTA
GCGTGGTCGTATGTTGTCTACTATAGTCCAAGTGAAGTTCGAGTGGTGGCAGAAGGATTT
GATTTTGCTAATGGAATCAACATTTCACCCGATGGCAAGTATGTCTATATAGCTGAGTTG
CTGGCTCATAAGATTCATGTGTATGAAAAGCATGCTAATTGGACTTTAACTCCATTGAAG
TCCCTTGACTTTAATACCCTCGTGGATAACATATCTGTGGATCCTGAGACAGGAGACCTT
TGGGTTGGATGCCATCCCAATGGCATGAAAATCTTCTTCTATGACTCAGAGAATCCTCCT
GCATCAGAGGTGCTTCGAATCCAGAACATTCTAACAGAAGAACCTAAAGTGACACAGGTT
TATGCAGAAAATGGCACAGTGTTGCAAGGCAGTACAGTTGCCTCTGTGTACAAAGGGAAA
CTGCTGATTGGCACAGTGTTTCACAAAGCTCTTTACTGTGAGCTCTAA
GenBank Gene IDM63012
GeneCard IDNot Available
GenAtlas IDPON1
HGNC IDHGNC:9204
Chromosome Location7
Locus7q21.3
References
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