Acetyl-CoA acetyltransferase, mitochondrial

NameAcetyl-CoA acetyltransferase, mitochondrial
Synonyms
  • 2.3.1.9
  • ACAT
  • Acetoacetyl-CoA thiolase
  • MAT
  • T2
Gene NameACAT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000138|Acetyl-CoA acetyltransferase, mitochondrial
MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLS
LLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCT
TINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIV
KDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTV
TVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADA
AKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVV
LANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGAS
AMLIQKL
Number of residues427
Molecular Weight45199.2
Theoretical pI9.21
GO Classification
Functions
  • acetyl-CoA C-acetyltransferase activity
  • coenzyme binding
  • metal ion binding
Processes
  • branched-chain amino acid catabolic process
  • cellular lipid metabolic process
  • brain development
  • cellular ketone body metabolic process
  • ketone body biosynthetic process
  • ketone body catabolic process
  • liver development
  • response to hormone
  • protein homooligomerization
  • response to starvation
  • response to organic cyclic compound
  • adipose tissue development
  • metanephric proximal convoluted tubule development
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
Components
  • extracellular exosome
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial matrix
General FunctionMetal ion binding
Specific FunctionPlays a major role in ketone body metabolism.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID219918
UniProtKB IDP24752
UniProtKB Entry NameTHIL_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0018914|Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
ATGGCTGTGCTGGCGGCACTTCTGCGCAGCGGCGCCCGCAGCCGCAGCCCCCTGCTCCGG
AGGCTGGTGCAGGAAATAAGATATGTGGAACGGAGTTATGTATCAAAACCCACTTTGAAG
GAAGTGGTCATAGTAAGTGCTACAAGAACACCCATTGGATCTTTTTTAGGCAGCCTTTCC
TTGCTGCCAGCCACTAAGCTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAGGG
ATTCCAAAAGAAGAAGTGAAAGAAGCATACATGGGTAATGTTCTACAAGGAGGTGAAGGA
CAAGCTCCTACAAGGCAGGCAGTATTGGGTGCAGGCTTACCTATTTCTACTCCATGTACC
ACCATAAACAAAGTTTGTGCTTCAGGAATGAAAGCCATCATGATGGCCTCTCAAAGTCTT
ATGTGTGGACATCAGGATGTGATGGTGGCAGGTGGGATGGAGAGCATGTCCAATGTTCCA
TATGTAATGAACAGAGGATCAACACCATATGGTGGGGTAAAGCTTGAAGATTTGATTGTA
AAAGACGGGCTAACTGATGTCTACAATAAAATTCATATGGGCAGCTGTGCTGAGAATACA
GCAAAGAAGCTGAATATTGCACGAAATGAACAGGACGCTTATGCTATTAATTCTTATACC
AGAAGTAAAGCAGCATGGGAAGCTGGGAAATTTGGAAATGAAGTTATTCCTGTCACAGTT
ACAGTAAAAGGTCAACCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGAT
TTTAGCAAAGTTCCAAAGCTGAAGACAGTTTTCCAGAAAGAAAATGGCACAGTAACAGCT
GCCAATGCCAGTACACTGAATGATGGAGCAGCTGCTCTGGTTCTCATGACGGCAGATGCA
GCGAAGAGGCTCAATGTTACACCACTGGCAAGAATAGTAGCATTTGCTGACGCTGCTGTA
GAACCTATTGATTTTCCAATTGCTCCTGTATATGCTGCATCTATGGTTCTTAAAGATGTG
GGATTGAAAAAAGAAGATATTGCAATGTGGGAAGTAAATGAAGCCTTTAGTCTGGTTGTA
CTAGCAAACATTAAAATGTTGGAGATTGATCCCCAAAAAGTGAATATCAATGGAGGAGCT
GTTTCTCTGGGACATCCAATTGGGATGTCTGGAGCCAGGATTGTTGGTCATTTGACTCAT
GCCTTGAAGCAAGGAGAATACGGTCTTGCCAGTATTTGCAATGGAGGAGGAGGTGCTTCT
GCCATGCTAATTCAGAAGCTGTAG
GenBank Gene IDD90228
GeneCard IDNot Available
GenAtlas IDACAT1
HGNC IDHGNC:93
Chromosome Location11
Locus11q22.3-q23.1
References
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