Low molecular weight phosphotyrosine protein phosphatase

NameLow molecular weight phosphotyrosine protein phosphatase
Synonyms
  • 3.1.3.48
  • Adipocyte acid phosphatase
  • LMW-PTP
  • Low molecular weight cytosolic acid phosphatase
  • Red cell acid phosphatase 1
Gene NameACP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007263|Low molecular weight phosphotyrosine protein phosphatase
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
Number of residues158
Molecular Weight18042.315
Theoretical pI6.73
GO Classification
Functions
  • non-membrane spanning protein tyrosine phosphatase activity
  • acid phosphatase activity
Components
  • extracellular exosome
  • cytoplasmic side of plasma membrane
  • cytoplasm
General FunctionNon-membrane spanning protein tyrosine phosphatase activity
Specific FunctionActs on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID179636
UniProtKB IDP24666
UniProtKB Entry NamePPAC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012643|Low molecular weight phosphotyrosine protein phosphatase (ACP1)
ATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCA
CCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGG
AGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGG
CAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGGTACCGTCC
TTGGACTTGAAGTTGTGTGTTTTGTGTTTCAGTGGGTCATTGACAGCGGTGCTGTTTCTG
ACTGGAACGTGGGCCGGTCCCCAGACCCAAGAGCTGTGA
GenBank Gene IDM83653
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:122
Chromosome Location2
Locus2p25
References
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  2. Dissing J, Johnsen AH: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles. Biochim Biophys Acta. 1992 Jun 24;1121(3):261-8. 1627603
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  4. Bryson GL, Massa H, Trask BJ, Van Etten RL: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. Genomics. 1995 Nov 20;30(2):133-40. 8586411
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