NameHistone H2B type 1-O
Synonyms
  • H2B/n
  • H2BFH
  • H2BFN
  • Histone H2B.2
  • Histone H2B.n
Gene NameHIST1H2BO
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013513|Histone H2B type 1-O
MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Number of residues126
Molecular Weight13906.025
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • nucleosome assembly
  • chromatin organization
Components
  • cytoplasm
  • nucleus
  • nucleoplasm
  • nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP23527
UniProtKB Entry NameH2B1O_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013514|Histone H2B type 1-O (HIST1H2BO)
ATGCCCGACCCGGCTAAATCTGCTCCTGCCCCCAAAAAGGGCTCCAAGAAAGCCGTAACC
AAGGCCCAGAAAAAGGACGGCAAGAAGCGCAAGCGCAGCCGCAAAGAGAGTTACTCTATC
TACGTGTACAAGGTGCTGAAGCAAGTCCACCCCGACACCGGCATCTCATCGAAGGCCATG
GGCATCATGAACTCCTTCGTCAATGACATCTTTGAGCGCATCGCTGGCGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCCGGGGAGCTGGCCAAGCACGCCGTGTCCGAGGGCACAAAGGCCGTCACC
AAGTACACCAGCTCCAAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4758
Chromosome Location6
LocusNot Available
References
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