NamePeptidyl-prolyl cis-trans isomerase B
Synonyms
  • 5.2.1.8
  • Cyclophilin B
  • CYP-S1
  • CYPB
  • PPIase B
  • Rotamase B
  • S-cyclophilin
  • SCYLP
Gene NamePPIB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037192|Peptidyl-prolyl cis-trans isomerase B
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRV
IFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYG
ERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVR
KVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Number of residues216
Molecular Weight23742.405
Theoretical pI9.97
GO Classification
Functions
  • unfolded protein binding
  • RNA polymerase binding
  • peptide binding
  • protein complex binding
  • poly(A) RNA binding
  • peptidyl-prolyl cis-trans isomerase activity
Processes
  • chaperone-mediated protein folding
  • protein peptidyl-prolyl isomerization
  • protein stabilization
  • positive regulation by host of viral genome replication
  • extracellular matrix organization
  • positive regulation by host of viral process
  • bone development
  • positive regulation of multicellular organism growth
Components
  • nucleus
  • endoplasmic reticulum
  • endoplasmic reticulum chaperone complex
  • extracellular exosome
  • macromolecular complex
  • perinuclear region of cytoplasm
  • endoplasmic reticulum lumen
  • focal adhesion
  • melanosome
  • smooth endoplasmic reticulum
  • membrane
General FunctionUnfolded protein binding
Specific FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181335
UniProtKB IDP23284
UniProtKB Entry NamePPIB_HUMAN
Cellular LocationEndoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0011677|Peptidyl-prolyl cis-trans isomerase B (PPIB)
ATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTCATCGCGGGG
TCCGTCTTCTTCCTGCTGCTGCCGGGACCTTCTGCGGCCGATGAGAAGAAGAAGGGGCCC
AAAGTCACCGTCAAGGTGTATTTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTG
ATCTTTGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTGGCCTTAGCT
ACAGGAGAGAAAGGATTTGGCTACAAAAACAGCAAATTCCATCGTGTAATCAAGGACTTC
ATGATCCAGGGCGGAGACTTCACCAGGGGAGATGGCACAGGAGGAAAGAGCATCTACGGT
GAGCGCTTCCCCGATGAGAACTTCAAACTGAAGCACTACGGGCCTGGCTGGGTGAGCATG
GCCAACGCAGGCAAAGACACCAACGGCTCCCAGTTCTTCATCACGACAGTCAAGACAGCC
TGGCTAGATGGCAAGCATGTGGTGTTTGGCAAAGTTCTAGAGGGCATGGAGGTGGTGCGG
AAGGTGGAGAGCACCAAGACAGACAGCCGGGATAAACCCCTGAAGGATGTGATCATCGCA
GACTGCGGCAAGATCGAGGTGGAGAAGCCCTTTGCCATCGCCAAGGAGTAG
GenBank Gene IDM60857
GeneCard IDNot Available
GenAtlas IDPPIB
HGNC IDHGNC:9255
Chromosome Location15
Locus15q21-q22
References
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