DNA repair protein complementing XP-A cells

NameDNA repair protein complementing XP-A cells
Synonyms
  • Xeroderma pigmentosum group A-complementing protein
  • XPAC
Gene NameXPA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013433|DNA repair protein complementing XP-A cells
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Number of residues273
Molecular Weight31367.71
Theoretical pINot Available
GO Classification
Functions
  • protein domain specific binding
  • metal ion binding
  • damaged DNA binding
  • protein homodimerization activity
Processes
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • multicellular organism growth
  • response to toxic substance
  • global genome nucleotide-excision repair
  • transcription-coupled nucleotide-excision repair
  • response to UV
  • nucleotide-excision repair, DNA incision
  • DNA repair
  • response to auditory stimulus
  • response to oxidative stress
  • nucleotide-excision repair
Components
  • nucleoplasm
  • cytoplasm
  • intercellular bridge
  • nucleus
  • Golgi apparatus
General FunctionProtein homodimerization activity
Specific FunctionInvolved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP23025
UniProtKB Entry NameXPA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013434|DNA repair protein complementing XP-A cells (XPA)
ATGGCGGCGGCCGACGGGGCTTTGCCGGAGGCGGCGGCTTTAGAGCAACCCGCGGAGCTG
CCTGCCTCGGTGCGGGCGAGTATCGAGCGGAAGCGGCAGCGGGCACTGATGCTGCGCCAG
GCCCGGCTGGCTGCCCGGCCCTACTCGGCGACGGCGGCTGCGGCTACTGGAGGCATGGCT
AATGTAAAAGCAGCCCCAAAGATAATTGACACAGGAGGAGGCTTCATTTTAGAAGAGGAA
GAAGAAGAAGAACAGAAAATTGGAAAAGTTGTTCATCAACCAGGACCTGTTATGGAATTT
GATTATGTAATATGCGAAGAATGTGGGAAAGAATTTATGGATTCTTATCTTATGAACCAC
TTTGATTTGCCAACTTGTGATAACTGCAGAGATGCTGATGATAAACACAAGCTTATAACC
AAAACAGAGGCAAAACAAGAATATCTTCTGAAAGACTGTGATTTAGAAAAAAGAGAGCCA
CCTCTTAAATTTATTGTGAAGAAGAATCCACATCATTCACAATGGGGTGATATGAAACTC
TACTTAAAGTTACAGATTGTGAAGAGGTCTCTTGAAGTTTGGGGTAGTCAAGAAGCATTA
GAAGAAGCAAAGGAAGTCCGACAGGAAAACCGAGAAAAAATGAAACAGAAGAAATTTGAT
AAAAAAGTAAAAGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAGGGAGACGATT
GTTCATCAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACT
TGTACTATGTGTGGCCATGAACTGACATATGAAAAAATGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12814
Chromosome Location9
LocusNot Available
References
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