Ferrochelatase, mitochondrial

NameFerrochelatase, mitochondrial
Synonyms
  • 4.99.1.1
  • Heme synthase
  • Protoheme ferro-lyase
Gene NameFECH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002057|Ferrochelatase, mitochondrial
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Number of residues423
Molecular Weight47861.77
Theoretical pI8.91
GO Classification
Functions
  • heme binding
  • 2 iron, 2 sulfur cluster binding
  • ferrochelatase activity
  • iron-responsive element binding
  • ferrous iron binding
Processes
  • regulation of hemoglobin biosynthetic process
  • response to ethanol
  • cellular response to dexamethasone stimulus
  • response to methylmercury
  • generation of precursor metabolites and energy
  • heme biosynthetic process
  • porphyrin-containing compound metabolic process
  • response to arsenic-containing substance
  • response to platinum ion
  • iron ion homeostasis
  • response to lead ion
  • response to drug
  • very-low-density lipoprotein particle assembly
  • response to insecticide
  • response to light stimulus
  • erythrocyte differentiation
  • protoporphyrinogen IX metabolic process
  • small molecule metabolic process
  • regulation of eIF2 alpha phosphorylation by heme
  • regulation of gene expression
  • detection of UV
  • cholesterol metabolic process
Components
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial matrix
General FunctionIron-responsive element binding
Specific FunctionCatalyzes the ferrous insertion into protoporphyrin IX.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID219656
UniProtKB IDP22830
UniProtKB Entry NameHEMH_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0019053|Ferrochelatase, mitochondrial (FECH)
ATGCGTTCACTCGGCGCAAACATGGCTGCGGCCCTGCGCGCCGCGGGCGTCCTGCTCCGC
GATCCGCTGGCATCCAGCAGCTGGAGGGTCTGTCAGCCATGGAGGTGGAAGTCAGGTGCA
GCTGCAGCGGCCGTCACCACAGAAACAGCCCAGCATGCCCAGGGTGCAAAACCTCAAGTT
CAACCGCAGAAGAGGAAGCCGAAAACTGGAATATTAATGCTAAACATGGGAGGCCCTGAA
ACTCTTGGAGATGTTCACGACTTCCTTCTGAGACTCTTCTTGGACCGAGACCTCATGACA
CTTCCTATTCAGAATAAGCTGGCACCATTCATCGCCAAACGCCGAACCCCCAAGATTCAA
GAGCAGTACCGCAGGATTGGAGGCGGATCCCCCATCAAGATATGGACTTCCAAGCAGGGA
GAGGGCATGGTGAAGCTGCTGGATGAATTGTCCCCCAACACAGCCCCTCACAAATACTAT
ATTGGATTTCGGTACGTCCATCCTTTAACAGAAGAAGCAATTGAAGAGATGGAGAGAGAT
GGCCTAGAAAGGGCTATTGCTTTCACACAGTATCCACAGTACAGCTGCTCCACCACAGGC
AGCAGCTTAAATGCCATTTACAGATACTATAATCAAGTGGGACGGAAGCCCACGATGAAG
TGGAGCACTATTGACAGGTGGCCCACACATCACCTCCTCATCCAGTGCTTTGCAGATCAT
ATTCTAAAGGAACTGGACCATTTTCCACTTGAGAAGAGAAGCGAGGTGGTCATTCTGTTT
TCTGCTCACTCACTGCCCATGTCTGTGGTCAACAGAGGCGACCCATATCCTCAGGAGGTA
AGCGCCACTGTCCAAAAAGTCATGGAAAGGCTGGAGTACTGCAACCCCTACCGACTGGTG
TGGCAATCCAAGGTTGGTCCAATGCCCTGGTTGGGTCCTCAAACAGACGAATCTATCAAA
GGGCTTTGTGAGAGGGGGAGGAAGAATATCCTCTTGGTTCCGATAGCATTTACCAGTGAC
CATATTGAAACGCTGTATGAGCTGGACATCGAGTACTCTCAAGTTTTAGCCAAGGAGTGT
GGAGTTGAAAACATCAGAAGAGCTGAGTCTCTTAATGGAAATCCATTGTTCTCTAAGGCC
CTGGCCGACTTGGTGCATTCACACATCCAGTCAAACGAGCTGTGTTCCAAGCAGCTGACC
CTGAGCTGTCCGCTCTGTGTCAATCCTGTCTGCAGGGAGACTAAATCCTTCTTCACCAGC
CAGCAGCTGTGA
GenBank Gene IDD00726
GeneCard IDNot Available
GenAtlas IDFECH
HGNC IDHGNC:3647
Chromosome Location18
Locus18q21.3
References
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