Carbonic anhydrase 4

NameCarbonic anhydrase 4
Synonyms
  • 4.2.1.1
  • CA-IV
  • Carbonate dehydratase IV
  • Carbonic anhydrase IV
Gene NameCA4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001068|Carbonic anhydrase 4
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
Number of residues312
Molecular Weight35032.075
Theoretical pI7.94
GO Classification
Functions
  • carbonate dehydratase activity
  • zinc ion binding
Processes
  • response to drug
  • response to steroid hormone
  • organ development
  • small molecule metabolic process
  • bicarbonate transport
  • one-carbon metabolic process
Components
  • endoplasmic reticulum-Golgi intermediate compartment
  • secretory granule membrane
  • plasma membrane
  • trans-Golgi network
  • cell surface
  • transport vesicle membrane
  • Golgi apparatus
  • extracellular exosome
  • perinuclear region of cytoplasm
  • apical plasma membrane
  • brush border membrane
  • sarcolemma
  • anchored component of external side of plasma membrane
  • sarcoplasmic reticulum
  • membrane
  • rough endoplasmic reticulum
General FunctionZinc ion binding
Specific FunctionReversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID179791
UniProtKB IDP22748
UniProtKB Entry NameCAH4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010374|Carbonic anhydrase 4 (CA4)
ATGCGGATGCTGCTGGCGCTCCTGGCCCTCTCCGCGGCGCGGCCATCGGCCAGTGCAGAG
TCACACTGGTGCTACGAGGTTCAAGCCGAGTCCTCCAACTACCCCTGCTTGGTGCCAGTC
AAGTGGGGTGGAAACTGCCAGAAGGACCGCCAGTCCCCCATCAACATCGTCACCACCAAG
GCAAAGGTGGACAAAAAACTGGGACGCTTCTTCTTCTCTGGCTACGATAAGAAGCAAACG
TGGACTGTCCAAAATAACGGGCACTCAGTGATGATGTTGCTGGAGAACAAGGCCAGCATT
TCTGGAGGAGGACTGCCTGCCCCATACCAGGCCAAACAGTTGCACCTGCACTGGTCCGAC
TTGCCATATAAGGGCTCGGAGCACAGCCTCGATGGGGAGCACTTTGCCATGGAGATGCAC
ATAGTACATGAGAAAGAGAAGGGGACATCGAGGAATGTGAAAGAGGCCCAGGACCCTGAA
GACGAAATTGCGGTGCTGGCCTTTCTGGTGGAGGCTGGAACCCAGGTGAACGAGGGCTTC
CAGCCACTGGTGGAGGCACTGTCTAATATCCCCAAACCTGAGATGAGCACTACGATGGCA
GAGAGCAGCCTGTTGGACCTGCTCCCCAAGGAGGAGAAACTGAGGCACTACTTCCGCTAC
CTGGGCTCACTCACCACACCGACCTGCGATGAGAAGGTCGTCTGGACTGTGTTCCGGGAG
CCCATTCAGCTTCACAGAGAACAGATCCTGGCATTCTCTCAGAAGCTGTACTACGACAAG
GAACAGACAGTGAGCATGAAGGACAATGTCAGGCCCCTGCAGCAGCTGGGGCAGCGCACG
GTGATAAAGTCCGGGGCCCCGGGTCGGCCGCTGCCCTGGGCCCTGCCTGCCCTGCTGGGC
CCCATGCTGGCCTGCCTGCTGGCCGGCTTCCTGCGATGA
GenBank Gene IDM83670
GeneCard IDNot Available
GenAtlas IDCA4
HGNC IDHGNC:1375
Chromosome Location17
Locus17q23
References
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