Catechol O-methyltransferase

NameCatechol O-methyltransferase
Synonyms
  • 2.1.1.6
Gene NameCOMT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004096|Catechol O-methyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Number of residues271
Molecular Weight30036.77
Theoretical pI5.15
GO Classification
Functions
  • catechol O-methyltransferase activity
  • O-methyltransferase activity
  • magnesium ion binding
Processes
  • dopamine catabolic process
  • female pregnancy
  • neurotransmitter biosynthetic process
  • cellular response to phosphate starvation
  • xenobiotic metabolic process
  • developmental process
  • multicellular organismal reproductive process
  • learning
  • negative regulation of dopamine metabolic process
  • estrogen metabolic process
  • response to drug
  • positive regulation of homocysteine metabolic process
  • negative regulation of renal sodium excretion
  • response to pain
  • synaptic transmission
  • regulation of sensory perception of pain
  • neurotransmitter catabolic process
  • methylation
  • small molecule metabolic process
  • short-term memory
  • negative regulation of smooth muscle cell proliferation
  • response to organic cyclic compound
  • response to lipopolysaccharide
Components
  • mitochondrion
  • cell body
  • membrane
  • postsynaptic membrane
  • plasma membrane
  • dendritic spine
  • axon
  • integral component of membrane
  • cytosol
  • extracellular exosome
General FunctionO-methyltransferase activity
Specific FunctionCatalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Pfam Domain Function
Transmembrane Regions7-26
GenBank Protein ID180920
UniProtKB IDP21964
UniProtKB Entry NameCOMT_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011516|Catechol O-methyltransferase (COMT)
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA
GenBank Gene IDM65212
GeneCard IDNot Available
GenAtlas IDCOMT
HGNC IDHGNC:2228
Chromosome Location22
Locus22q11.21-q11.23|22q11.21
References
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