Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

NameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms
  • 1.3.5.1
  • Ip
  • Iron-sulfur subunit of complex II
  • SDH
  • SDH1
Gene NameSDHB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011624|Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
Number of residues280
Molecular Weight31629.365
Theoretical pI8.92
GO Classification
Functions
  • metal ion binding
  • electron carrier activity
  • 4 iron, 4 sulfur cluster binding
  • ubiquinone binding
  • 2 iron, 2 sulfur cluster binding
  • 3 iron, 4 sulfur cluster binding
  • succinate dehydrogenase (ubiquinone) activity
Processes
  • aerobic respiration
  • small molecule metabolic process
  • cellular metabolic process
  • respiratory electron transport chain
  • succinate metabolic process
  • tricarboxylic acid cycle
Components
  • plasma membrane
  • extracellular exosome
  • nucleoplasm
  • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
  • mitochondrion
  • mitochondrial inner membrane
General FunctionUbiquinone binding
Specific FunctionIron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID665925
UniProtKB IDP21912
UniProtKB Entry NameSDHB_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0011625|Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB)
ATGGCGGCGGTGGTCGCCCTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGGA
GCCTGCCTGCAGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACAGCTCCCCGTATCAAG
AAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTCATATGCAGACT
TATGAAGTTGACCTTAATAAATGTGGCCCCATGGTATTGGATGCTTTAATCAAGATTAAG
AATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGCATCTGTGGCTCT
TGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGATTGACACCAAC
CTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTT
CCCGATTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAG
GATGAATCTCAGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTG
GACGGGCTCTACGAGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGG
TGGAACGGAGACAAATATCTGGGGCCTGCAGTTCTTATGCAGGCCTATCGCTGGATGATT
GACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGCTGCAGGACCCATTCTCTCTA
TACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGGTCTGAATCCAGGG
AAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGCTTCAGTT
TAA
GenBank Gene IDU17248
GeneCard IDNot Available
GenAtlas IDSDHB
HGNC IDHGNC:10681
Chromosome Location1
Locus1p36.1-p35
References
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