Tumor necrosis factor receptor superfamily member 1B

NameTumor necrosis factor receptor superfamily member 1B
Synonyms
  • p75
  • p80 TNF-alpha receptor
  • TNF-R2
  • TNF-RII
  • TNFBR
  • TNFR-II
  • TNFR2
  • Tumor necrosis factor receptor 2
  • Tumor necrosis factor receptor type II
Gene NameTNFRSF1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001890|Tumor necrosis factor receptor superfamily member 1B
MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPG
QHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTC
RPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICR
PHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTS
FLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKV
PHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGE
ARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQ
VPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
Number of residues461
Molecular Weight48290.85
Theoretical pI6.22
GO Classification
Functions
  • tumor necrosis factor-activated receptor activity
  • ubiquitin protein ligase binding
Processes
  • cellular response to growth factor stimulus
  • tumor necrosis factor-mediated signaling pathway
  • inflammatory response
  • extrinsic apoptotic signaling pathway
  • regulation of apoptotic process
  • positive regulation of membrane protein ectodomain proteolysis
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • regulation of cell proliferation
  • RNA destabilization
  • multicellular organismal development
  • negative regulation of inflammatory response
  • cellular response to lipopolysaccharide
  • apoptotic signaling pathway
  • aging
  • positive regulation of MAPK cascade
  • immune response
Components
  • plasma membrane
  • perinuclear region of cytoplasm
  • varicosity
  • integral component of plasma membrane
  • membrane raft
  • neuronal cell body
  • extracellular region
  • nucleus
General FunctionUbiquitin protein ligase binding
Specific FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Pfam Domain Function
Transmembrane Regions258-287
GenBank Protein ID189186
UniProtKB IDP20333
UniProtKB Entry NameTNR1B_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016265|Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
ATGGCGCCCGTCGCCGTCTGGGCCGCGCTGGCCGTCGGACTGGAGCTCTGGGCTGCGGCG
CACGCCTTGCCCGCCCAGGTGGCATTTACACCCTACGCCCCGGAGCCCGGGAGCACATGC
CGGCTCAGAGAATACTATGACCAGACAGCTCAGATGTGCTGCAGCAAATGCTCGCCGGGC
CAACATGCAAAAGTCTTCTGTACCAAGACCTCGGACACCGTGTGTGACTCCTGTGAGGAC
AGCACATACACCCAGCTCTGGAACTGGGTTCCCGAGTGCTTGAGCTGTGGCTCCCGCTGT
AGCTCTGACCAGGTGGAAACTCAAGCCTGCACTCGGGAACAGAACCGCATCTGCACCTGC
AGGCCCGGCTGGTACTGCGCGCTGAGCAAGCAGGAGGGGTGCCGGCTGTGCGCGCCGCTG
CGCAAGTGCCGCCCGGGCTTCGGCGTGGCCAGACCAGGAACTGAAACATCAGACGTGGTG
TGCAAGCCCTGTGCCCCGGGGACGTTCTCCAACACGACTTCATCCACGGATATTTGCAGG
CCCCACCAGATCTGTAACGTGGTGGCCATCCCTGGGAATGCAAGCATGGATGCAGTCTGC
ACGTCCACGTCCCCCACCCGGAGTATGGCCCCAGGGGCAGTACACTTACCCCAGCCAGTG
TCCACACGATCCCAACACACGCAGCCAACTCCAGAACCCAGCACTGCTCCAAGCACCTCC
TTCCTGCTCCCAATGGGCCCCAGCCCCCCAGCTGAAGGGAGCACTGGCGACTTCGCTCTT
CCAGTTGGACTGATTGTGGGTGTGACAGCCTTGGGTCTACTAATAATAGGAGTGGTGAAC
TGTGTCATCATGACCCAGGTGAAAAAGAAGCCCTTGTGCCTGCAGAGAGAAGCCAAGGTG
CCTCACTTGCCTGCCGATAAGGCCCGGGGTACACAGGGCCCCGAGCAGCAGCACCTGCTG
ATCACAGCGCCGAGCTCCAGCAGCAGCTCCCTGGAGAGCTCGGCCAGTGCGTTGGACAGA
AGGGCGCCCACTCGGAACCAGCCACAGGCACCAGGCGTGGAGGCCAGTGGGGCCGGGGAG
GCCCGGGCCAGCACCGGGAGCTCAGATTCTTCCCCTGGTGGCCATGGGACCCAGGTCAAT
GTCACCTGCATCGTGAACGTCTGTAGCAGCTCTGACCACAGCTCACAGTGCTCCTCCCAA
GCCAGCTCCACAATGGGAGACACAGATTCCAGCCCCTCGGAGTCCCCGAAGGACGAGCAG
GTCCCCTTCTCCAAGGAGGAATGTGCCTTTCGGTCACAGCTGGAGACGCCAGAGACCCTG
CTGGGGAGCACCGAAGAGAAGCCCCTGCCCCTTGGAGTGCCTGATGCTGGGATGAAGCCC
AGTTAA
GenBank Gene IDM32315
GeneCard IDNot Available
GenAtlas IDTNFRSF1B
HGNC IDHGNC:11917
Chromosome Location1
Locus1p36.3-p36.2
References
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