Retinoic acid receptor RXR-alpha

NameRetinoic acid receptor RXR-alpha
Synonyms
  • NR2B1
  • Nuclear receptor subfamily 2 group B member 1
  • Retinoid X receptor alpha
Gene NameRXRA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000821|Retinoic acid receptor RXR-alpha
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Number of residues462
Molecular Weight50810.835
Theoretical pI7.86
GO Classification
Functions
  • 9-cis retinoic acid receptor activity
  • retinoic acid-responsive element binding
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • vitamin D receptor binding
  • zinc ion binding
  • steroid hormone receptor activity
  • DNA binding
  • protein heterodimerization activity
  • chromatin DNA binding
  • retinoic acid receptor activity
  • transcription factor activity, sequence-specific DNA binding
  • enzyme binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
  • sequence-specific DNA binding
  • transcription coactivator activity
Processes
  • cholesterol metabolic process
  • gene expression
  • regulation of myelination
  • small molecule metabolic process
  • liver development
  • transcription initiation from RNA polymerase II promoter
  • response to ethanol
  • in utero embryonic development
  • response to retinoic acid
  • aging
  • axon regeneration
  • response to vitamin D
  • response to selenium ion
  • positive regulation of apoptotic process
  • bile acid and bile salt transport
  • retinoic acid receptor signaling pathway
  • response to vitamin A
  • negative regulation of cell proliferation
  • maternal placenta development
  • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
  • midgut development
  • positive regulation of transcription from RNA polymerase II promoter
  • modulation by virus of host morphology or physiology
  • ventricular cardiac muscle cell differentiation
  • peroxisome proliferator activated receptor signaling pathway
  • ventricular cardiac muscle tissue morphogenesis
  • vitamin metabolic process
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
  • protein homotetramerization
  • positive regulation of translational initiation by iron
  • embryo implantation
  • response to glucocorticoid
  • regulation of branching involved in prostate gland morphogenesis
  • inflammatory response
  • negative regulation of transcription from RNA polymerase II promoter
  • cellular response to insulin stimulus
  • camera-type eye development
  • cellular lipid metabolic process
  • bile acid metabolic process
Components
  • RNA polymerase II transcription factor complex
  • nucleoplasm
  • nuclear chromatin
  • nucleus
  • receptor complex
  • axon
General FunctionZinc ion binding
Specific FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID35885
UniProtKB IDP19793
UniProtKB Entry NameRXRA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0000820|1389 bp
ATGGACACCAAACATTTCCTGCCGCTCGATTTCTCCACCCAGGTGAACTCCTCCCTCACC
TCCCCGACGGGGCGAGGCTCCATGGCTGCCCCCTCGCTGCACCCGTCCCTGGGGCCTGGC
ATCGGCTCCCCGGGACAGCTGCATTCTCCCATCAGCACCCTGAGCTCCCCCATCAACGGC
ATGGGCCCGCCTTTCTCGGTCATCAGCTCCCCCATGGGCCCCCACTCCATGTCGGTGCCC
ACCACACCCACCCTGGGCTTCAGCACTGGCAGCCCCCAGCTCAGCTCACCTATGAACCCC
GTCAGCAGCAGCGAGGACATCAAGCCCCCCCTGGGCCTCAATGGCGTCCTCAAGGTCCCC
GCCCACCCCTCAGGAAACATGGCTTCCTTCACCAAGCACATCTGCGCCATCTGCGGGGAC
CGCTCCTCAGGCAAGCACTATGGAGTGTACAGCTGCGAGGGGTGCAAGGGCTTCTTCAAG
CGGACGGTGCGCAAGGACCTGACCTACACCTGCCGCGACAACAAGGACTGCCTGATTGAC
AAGCGGCAGCGGAACCGGTGCCAGTACTGCCGCTACCAGAAGTGCCTGGCCATGGGCATG
AAGCGGGAAGCCGTGCAGGAGGAGCGGCAGCGTGGCAAGGACCGGAACGAGAATGAGGTG
GAGTCGACCAGCAGCGCCAACGAGGACATGCCGGTGGAGAGGATCCTGGAGGCTGAGCTG
GCCGTGGAGCCCAAGACCGAGACCTACGTGGAGGCAAACATGGGGCTGAACCCCAGCTCG
CCGAACGACCCTGTCACCAACATTTGCCAAGCAGCCGACAAACAGCTTTTCACCCTGGTG
GAGTGGGCCAAGCGGATCCCACACTTCTCAGAGCTGCCCCTGGACGACCAGGTCATCCTG
CTGCGGGCAGGCTGGAATGAGCTGCTCATCGCCTCCTTCTCCCACCGCTCCATCGCCGTG
AAGGACGGGATCCTCCTGGCCACCGGGCTGCACGTCCACCGGAACAGCGCCCACAGCGCA
GGGGTGGGCGCCATCTTTGACAGGGTGCTGACGGAGCTTGTGTCCAAGATGCGGGACATG
CAGATGGACAAGACGGAGCTGGGCTGCCTGCGCGCCATCGTCCTCTTTAACCCTGACTCC
AAGGGGCTCTCGAACCCGGCCGAGGTGGAGGCGCTGAGGGAGAAGGTCTATGCGTCCTTG
GAGGCCTACTGCAAGCACAAGTACCCAGAGCAGCCGGGAAGGTTCGCTAAGCTCTTGCTC
CGCCTGCCGGCTCTGCGCTCCATCGGGCTCAAATGCCTGGAACATCTCTTCTTCTTCAAG
CTCATCGGGGACACACCCATTGACACCTTCCTTATGGAGATGCTGGAGGCGCCGCACCAA
ATGACTTAG
GenBank Gene IDX52773
GeneCard IDNot Available
GenAtlas IDRXRA
HGNC IDHGNC:10477
Chromosome LocationNot Available
Locus9q34.3
References
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