DNA-directed RNA polymerases I, II, and III subunit RPABC1

NameDNA-directed RNA polymerases I, II, and III subunit RPABC1
Synonyms
  • DNA-directed RNA polymerase II 23 kDa polypeptide
  • DNA-directed RNA polymerase II subunit E
  • RNA polymerases I, II, and III subunit ABC1
  • RPB5 homolog
  • XAP4
Gene NamePOLR2E
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012582|DNA-directed RNA polymerases I, II, and III subunit RPABC1
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Number of residues210
Molecular Weight24551.075
Theoretical pI5.76
GO Classification
Functions
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • transcription from RNA polymerase I promoter
  • negative regulation of gene expression, epigenetic
  • transcription from RNA polymerase III promoter
  • regulation of gene expression, epigenetic
  • transcription initiation from RNA polymerase I promoter
  • positive regulation of type I interferon production
  • DNA repair
  • 7-methylguanosine mRNA capping
  • gene silencing by RNA
  • nucleotide-excision repair
  • mRNA splicing, via spliceosome
  • transcription from RNA polymerase II promoter
  • piRNA metabolic process
  • positive regulation of viral transcription
  • gene expression
  • RNA splicing
  • transcription initiation from RNA polymerase II promoter
  • transcription elongation from RNA polymerase II promoter
  • termination of RNA polymerase I transcription
  • innate immune response
  • termination of RNA polymerase III transcription
  • somatic stem cell population maintenance
  • transcription elongation from RNA polymerase I promoter
  • transcription-coupled nucleotide-excision repair
  • transcription elongation from RNA polymerase III promoter
  • viral process
Components
  • nucleus
  • DNA-directed RNA polymerase II, core complex
  • cytosol
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • nucleoplasm
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID232954
UniProtKB IDP19388
UniProtKB Entry NameRPAB1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0012583|DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)
ATGGACGACGAGGAGGAGACGTACCGGCTCTGGAAAATCCGCAAGACCATCATGCAGCTG
TGCCACGACCGTGGCTATCTGGTGACCCAGGACGAGCTTGACCAGACCCTGGAGGAGTTC
AAAGCCCAATTTGGGGACAAGCCGAGTGAGGGGCGGCCGCGGCGCACGGACCTCACCGTG
CTGGTGGCCCACAACGATGACCCCACCGACCAGATGTTTGTGTTCTTTCCAGAGGAGCCC
AAGGTGGGCATCAAGACCATCAAGGTGTACTGCCAGCGCATGCAGGAGGAGAACATCACA
CGGGCTCTCATCGTGGTGCAGCAGGGCATGACACCCTCCGCCAAGCAGTCCCTGGTCGAC
ATGGCCCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGGAGCTGCTCATCAACATCACG
GAGCACGAGCTAGTCCCTGAGCACGTCGTCATGACCAAGGAGGAGGTGACAGAGCTGCTG
GCCCGATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACCCTGTGGCG
CGCTACTTTGGGATAAAGCGTGGGCAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCT
GGCAGGTACATCACCTACCGGCTGGTGCAGTAG
GenBank Gene IDS42643
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9192
Chromosome Location19
Locus19p13.3
References
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