Name3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms
  • 1.3.1.22
  • S5AR 1
  • SR type 1
  • Steroid 5-alpha-reductase 1
Gene NameSRD5A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010375|3-oxo-5-alpha-steroid 4-dehydrogenase 1
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
Number of residues259
Molecular Weight29458.18
Theoretical pI9.07
GO Classification
Functions
  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity
  • cholestenone 5-alpha-reductase activity
  • electron carrier activity
Processes
  • small molecule metabolic process
  • cell differentiation
  • steroid metabolic process
  • androgen biosynthetic process
  • sex determination
  • sex differentiation
Components
  • integral component of membrane
  • endoplasmic reticulum membrane
General FunctionElectron carrier activity
Specific FunctionConverts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Pfam Domain Function
Transmembrane Regions12-29 86-106 111-131 151-171 209-229
GenBank Protein ID177767
UniProtKB IDP18405
UniProtKB Entry NameS5A1_HUMAN
Cellular LocationMicrosome membrane
Gene sequence
>lcl|BSEQ0010376|3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG
TGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGC
CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC
AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA
ATTTACCCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCG
ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG
TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACG
GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT
ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT
GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT
TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC
CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA
GenBank Gene IDM32313
GeneCard IDNot Available
GenAtlas IDSRD5A1
HGNC IDHGNC:11284
Chromosome Location5
Locus5p15
References
  1. Andersson S, Russell DW: Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A. 1990 May;87(10):3640-4. 2339109
  2. Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW: Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics. 1991 Dec;11(4):1102-12. 1686016
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