Tyrosine-protein phosphatase non-receptor type 1

NameTyrosine-protein phosphatase non-receptor type 1
Synonyms
  • 3.1.3.48
  • Protein-tyrosine phosphatase 1B
  • PTP-1B
  • PTP1B
Gene NamePTPN1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0018983|Tyrosine-protein phosphatase non-receptor type 1
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
Number of residues435
Molecular Weight49966.44
Theoretical pI6.21
GO Classification
Functions
  • zinc ion binding
  • receptor tyrosine kinase binding
  • poly(A) RNA binding
  • protein tyrosine phosphatase activity
  • enzyme binding
  • ephrin receptor binding
  • protein kinase binding
Processes
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
  • protein dephosphorylation
  • blood coagulation
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • negative regulation of vascular endothelial growth factor receptor signaling pathway
  • regulation of type I interferon-mediated signaling pathway
  • regulation of signal transduction
  • type I interferon signaling pathway
  • platelet activation
  • activation of signaling protein activity involved in unfolded protein response
  • actin cytoskeleton reorganization
  • negative regulation of PERK-mediated unfolded protein response
  • interferon-gamma-mediated signaling pathway
  • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
  • regulation of interferon-gamma-mediated signaling pathway
  • positive regulation of IRE1-mediated unfolded protein response
  • negative regulation of MAP kinase activity
  • platelet-derived growth factor receptor-beta signaling pathway
  • positive regulation of receptor catabolic process
  • IRE1-mediated unfolded protein response
  • regulation of endocytosis
  • regulation of hepatocyte growth factor receptor signaling pathway
  • negative regulation of ERK1 and ERK2 cascade
  • activation of JUN kinase activity
  • regulation of intracellular protein transport
  • insulin receptor signaling pathway
  • positive regulation of protein tyrosine kinase activity
  • cytokine-mediated signaling pathway
  • negative regulation of insulin receptor signaling pathway
  • peptidyl-tyrosine dephosphorylation
  • endoplasmic reticulum unfolded protein response
Components
  • endoplasmic reticulum
  • cytoplasmic side of endoplasmic reticulum membrane
  • sorting endosome
  • early endosome
  • cytoplasmic vesicle
  • cytosol
General FunctionZinc ion binding
Specific FunctionTyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190742
UniProtKB IDP18031
UniProtKB Entry NamePTN1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0018984|Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)
ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGT
CACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTG
ATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG
ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTAT
ACAGTGCGACAGCTAGAATTGGAAAACCTTACAACCCAAGAAACTCGAGAGATCTTACAT
TTCCACTATACCACATGGCCTGACTTTGGAGTCCCTGAATCACCAGCCTCATTCTTGAAC
TTTCTTTTCAAAGTCCGAGAGTCAGGGTCACTCAGCCCGGAGCACGGGCCCGTTGTGGTG
CACTGCAGTGCAGGCATCGGCAGGTCTGGAACCTTCTGTCTGGCTGATACCTGCCTCTTG
CTGATGGACAAGAGGAAAGACCCTTCTTCCGTTGATATCAAGAAAGTGCTGTTAGAAATG
AGGAAGTTTCGGATGGGGCTGATCCAGACAGCCGACCAGCTGCGCTTCTCCTACCTGGCT
GTGATCGAAGGTGCCAAATTCATCATGGGGGACTCTTCCGTGCAGGATCAGTGGAAGGAG
CTTTCCCACGAGGACCTGGAGCCCCCACCCGAGCATATCCCCCCACCTCCCCGGCCACCC
AAACGAATCCTGGAGCCACACAATGGGAAATGCAGGGAGTTCTTCCCAAATCACCAGTGG
GTGAAGGAAGAGACCCAGGAGGATAAAGACTGCCCCATCAAGGAAGAAAAAGGAAGCCCC
TTAAATGCCGCACCCTACGGCATCGAAAGCATGAGTCAAGACACTGAAGTTAGAAGTCGG
GTCGTGGGGGGAAGTCTTCGAGGTGCCCAGGCTGCCTCCCCAGCCAAAGGGGAGCCGTCA
CTGCCCGAGAAGGACGAGGACCATGCACTGAGTTACTGGAAGCCCTTCCTGGTCAACATG
TGCGTGGCTACGGTCCTCACGGCCGGCGCTTACCTCTGCTACAGGTTCCTGTTCAACAGC
AACACATAG
GenBank Gene IDM31724
GeneCard IDNot Available
GenAtlas IDPTPN1
HGNC IDHGNC:9642
Chromosome Location20
Locus20q13.1-q13.2
References
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