Tyrosine-protein phosphatase non-receptor type 2

NameTyrosine-protein phosphatase non-receptor type 2
Synonyms
  • 3.1.3.48
  • PTPT
  • T-cell protein-tyrosine phosphatase
  • TCPTP
Gene NamePTPN2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009001|Tyrosine-protein phosphatase non-receptor type 2
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Number of residues415
Molecular Weight48472.94
Theoretical pINot Available
GO Classification
Functions
  • receptor tyrosine kinase binding
  • protein tyrosine phosphatase activity
  • integrin binding
  • syntaxin binding
  • protein kinase binding
Processes
  • B cell differentiation
  • erythrocyte differentiation
  • negative regulation of ERK1 and ERK2 cascade
  • negative regulation of interferon-gamma-mediated signaling pathway
  • negative regulation of tumor necrosis factor-mediated signaling pathway
  • negative regulation of insulin receptor signaling pathway
  • regulation of hepatocyte growth factor receptor signaling pathway
  • peptidyl-tyrosine dephosphorylation
  • glucose homeostasis
  • negative regulation of platelet-derived growth factor receptor-beta signaling pathway
  • negative regulation of interleukin-2-mediated signaling pathway
  • negative regulation of macrophage differentiation
  • negative regulation of interleukin-4-mediated signaling pathway
  • negative regulation of epidermal growth factor receptor signaling pathway
  • insulin receptor signaling pathway
  • negative regulation of macrophage colony-stimulating factor signaling pathway
  • negative regulation of lipid storage
  • negative regulation of cell proliferation
  • negative regulation of positive thymic T cell selection
  • negative regulation of tyrosine phosphorylation of Stat3 protein
  • negative regulation of inflammatory response
  • negative regulation of prolactin signaling pathway
  • negative regulation of interleukin-6-mediated signaling pathway
  • cytokine-mediated signaling pathway
  • negative regulation of type I interferon-mediated signaling pathway
  • negative regulation of tyrosine phosphorylation of Stat5 protein
  • negative regulation of tyrosine phosphorylation of Stat1 protein
  • negative regulation of tyrosine phosphorylation of Stat6 protein
  • negative regulation of protein tyrosine kinase activity
  • negative regulation of chemotaxis
  • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
  • negative regulation of T cell receptor signaling pathway
  • interferon-gamma-mediated signaling pathway
  • positive regulation of PERK-mediated unfolded protein response
  • T cell differentiation
  • regulation of interferon-gamma-mediated signaling pathway
  • positive regulation of gluconeogenesis
Components
  • nucleus
  • endoplasmic reticulum
  • plasma membrane
  • nucleoplasm
  • endoplasmic reticulum-Golgi intermediate compartment
General FunctionSyntaxin binding
Specific FunctionNon-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP17706
UniProtKB Entry NamePTN2_HUMAN
Cellular LocationEndoplasmic reticulum
Gene sequence
>lcl|BSEQ0020842|Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)
ATGCCCACCACCATCGAGCGGGAGTTCGAAGAGTTGGATACTCAGCGTCGCTGGCAGCCG
CTGTACTTGGAAATTCGAAATGAGTCCCATGACTATCCTCATAGAGTGGCCAAGTTTCCA
GAAAACAGAAATCGAAACAGATACAGAGATGTAAGCCCATATGATCACAGTCGTGTTAAA
CTGCAAAATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAA
AGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTGCCATTTCTGGCTTATG
GTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCG
GTTAAATGTGCACAGTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGA
TTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATACAGTACATCTACTACAA
TTAGAAAATATCAATTATATTGAGAACTTGTGGATCACACTGTATTTGAAATTATTAATG
CTGGATGTTAAAAGGTCACTAAAAAGTGGTGAAACCAGAACAATATCTCACTTTCATTAT
ACTACCTGGCCAGATTTTGGAGTCCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTT
AAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCACTGTAGT
GCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAA
AAAGGAGATGATATTAACATAAAACAAGTGTTACTGAACATGAGAAAATACCGAATGGGT
CTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGGAGCAAAA
TGTATAAAGGGAGATTCTAGTATACAGAAACGATGGAAAGAACTTTCTAAGGAAGACTTA
TCTCCTGCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGA
ATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGATGTACAGGACTTTCCTCTAAAATG
CAAGATACAATGGAGGAGAACAGTGAGAGTGCTCTACGGAAACGTATTCGAGAGGACAGA
AAGGCCACCACAGCTCAGAAGGTGCAGCAGATGAAACAGAGGCTAAATGAGAATGAACGA
AAAAGAAAAAGGCCAAGATTGACAGACACCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9650
Chromosome Location18
LocusNot Available
References
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