Cyclic AMP-responsive element-binding protein 1

NameCyclic AMP-responsive element-binding protein 1
Synonyms
  • CREB-1
Gene NameCREB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001907|Cyclic AMP-responsive element-binding protein 1
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Number of residues341
Molecular Weight36687.86
Theoretical pI5.24
GO Classification
Functions
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II activating transcription factor binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • enzyme binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • transcription cofactor activity
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • transcription factor activity, sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • cAMP response element binding
Processes
  • protein phosphorylation
  • circadian rhythm
  • response to drug
  • positive regulation of transforming growth factor beta3 production
  • positive regulation of fat cell differentiation
  • protein stabilization
  • synaptic transmission
  • positive regulation of osteoclast differentiation
  • activation of phospholipase C activity
  • positive regulation of lipid biosynthetic process
  • MyD88-dependent toll-like receptor signaling pathway
  • phosphatidylinositol-mediated signaling
  • lactation
  • MyD88-independent toll-like receptor signaling pathway
  • memory
  • stress-activated MAPK cascade
  • transforming growth factor beta receptor signaling pathway
  • regulation of apoptotic process
  • toll-like receptor 10 signaling pathway
  • toll-like receptor 2 signaling pathway
  • Type I pneumocyte differentiation
  • cellular response to zinc ion
  • axon guidance
  • toll-like receptor 3 signaling pathway
  • Notch signaling pathway
  • epidermal growth factor receptor signaling pathway
  • toll-like receptor 4 signaling pathway
  • pituitary gland development
  • positive regulation of hormone secretion
  • innate immune response
  • toll-like receptor 5 signaling pathway
  • positive regulation of multicellular organism growth
  • negative regulation of transcription by competitive promoter binding
  • Fc-epsilon receptor signaling pathway
  • toll-like receptor 9 signaling pathway
  • toll-like receptor signaling pathway
  • viral process
  • lung saccule development
  • positive regulation of transcription, DNA-templated
  • toll-like receptor TLR1
  • regulation of circadian rhythm
  • secretory granule organization
  • fibroblast growth factor receptor signaling pathway
  • toll-like receptor TLR6
  • response to organic substance
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • TRIF-dependent toll-like receptor signaling pathway
  • signal transduction
  • response to glucagon
  • regulation of cell size
Components
  • nuclear euchromatin
  • nucleus
  • ATF4-CREB1 transcription factor complex
  • nucleoplasm
  • mitochondrion
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionPhosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID240429
UniProtKB IDP16220
UniProtKB Entry NameCREB1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021836|Cyclic AMP-responsive element-binding protein 1 (CREB1)
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA
GenBank Gene IDS72459
GeneCard IDNot Available
GenAtlas IDCREB1
HGNC IDHGNC:2345
Chromosome Location2
Locus2q34
References
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