Carbonyl reductase [NADPH] 1

NameCarbonyl reductase [NADPH] 1
Synonyms
  • 1.1.1.184
  • 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
  • CBR
  • CRN
  • NADPH-dependent carbonyl reductase 1
  • Prostaglandin 9-ketoreductase
  • Prostaglandin-E(2) 9-reductase
  • SDR21C1
  • Short chain dehydrogenase/reductase family 21C member 1
Gene NameCBR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006005|Carbonyl reductase [NADPH] 1
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
Number of residues277
Molecular Weight30374.73
Theoretical pI8.49
GO Classification
Functions
  • 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
  • prostaglandin-E2 9-reductase activity
  • carbonyl reductase (NADPH) activity
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Processes
  • arachidonic acid metabolic process
  • drug metabolic process
  • cyclooxygenase pathway
  • epithelial cell differentiation
  • vitamin K metabolic process
  • small molecule metabolic process
  • oxidation-reduction process
Components
  • extracellular vesicle
  • cytosol
  • extracellular exosome
General FunctionProstaglandin-e2 9-reductase activity
Specific FunctionNADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP16152
UniProtKB Entry NameCBR1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012150|Carbonyl reductase [NADPH] 1 (CBR1)
ATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCC
ATCGTGCGCGACCTGTGCCGGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTG
ACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCCCGCGCTTCCAC
CAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAG
TACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGTTGCTGATCCC
ACACCCTTTCATATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGAT
GTGTGCACAGAATTACTCCCTCTAATAAAACCCCAAGCATCCTGCGTACTGTCTGCATGG
TCATGCCTCTCCCAAAATCCTTCAGGAGGAAAGTCCAAGCCCTTAGCATGGTTCACAGAG
ATGTCCATAATCTGCCGCTGCTTAACTCTGGGCCCATTTTAA
GenBank Gene IDJ04056
GeneCard IDNot Available
GenAtlas IDCBR1
HGNC IDHGNC:1548
Chromosome Location21
LocusNot Available
References
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  2. Forrest GL, Akman S, Krutzik S, Paxton RJ, Sparkes RS, Doroshow J, Felsted RL, Glover CJ, Mohandas T, Bachur NR: Induction of a human carbonyl reductase gene located on chromosome 21. Biochim Biophys Acta. 1990 Apr 6;1048(2-3):149-55. 2182121
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