Vascular endothelial growth factor A

NameVascular endothelial growth factor A
Synonyms
  • Vascular permeability factor
  • VEGF
  • VEGF-A
  • VPF
Gene NameVEGFA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000325|Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Number of residues232
Molecular Weight27042.205
Theoretical pI9.08
GO Classification
Functions
  • fibronectin binding
  • protein homodimerization activity
  • protein heterodimerization activity
  • vascular endothelial growth factor receptor 1 binding
  • vascular endothelial growth factor receptor binding
  • heparin binding
  • identical protein binding
  • chemoattractant activity
  • extracellular matrix binding
  • growth factor activity
  • cytokine activity
  • platelet-derived growth factor receptor binding
  • neuropilin binding
  • receptor agonist activity
  • vascular endothelial growth factor receptor 2 binding
Processes
  • patterning of blood vessels
  • cell migration involved in sprouting angiogenesis
  • lymph vessel morphogenesis
  • positive regulation of cell proliferation
  • artery morphogenesis
  • cell maturation
  • commissural neuron axon guidance
  • positive regulation of protein kinase D signaling
  • positive regulation of neuroblast proliferation
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of endothelial cell proliferation
  • positive regulation of protein localization to early endosome
  • kidney development
  • positive regulation of receptor internalization
  • positive regulation of axon extension involved in axon guidance
  • positive regulation of protein phosphorylation
  • macrophage differentiation
  • branching morphogenesis of an epithelial tube
  • positive regulation of mast cell chemotaxis
  • primitive erythrocyte differentiation
  • negative regulation of transcription from RNA polymerase II promoter
  • surfactant homeostasis
  • positive regulation of peptidyl-tyrosine autophosphorylation
  • positive regulation of CREB transcription factor activity
  • positive regulation of cell division
  • camera-type eye morphogenesis
  • angiogenesis
  • endothelial cell chemotaxis
  • positive regulation of cell migration
  • regulation of transcription from RNA polymerase II promoter
  • positive regulation of vascular permeability
  • blood coagulation
  • mammary gland alveolus development
  • positive regulation of positive chemotaxis
  • coronary artery morphogenesis
  • lung development
  • positive regulation of leukocyte migration
  • cellular response to vascular endothelial growth factor stimulus
  • positive regulation of focal adhesion assembly
  • positive regulation of MAP kinase activity
  • positive regulation of protein autophosphorylation
  • positive regulation of retinal ganglion cell axon guidance
  • negative regulation of apoptotic process
  • ovarian follicle development
  • positive regulation of protein kinase C signaling
  • positive regulation of cellular component movement
  • regulation of cGMP metabolic process
  • positive regulation of p38MAPK cascade
  • regulation of retinal ganglion cell axon guidance
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of cell adhesion
  • vascular endothelial growth factor signaling pathway
  • dopaminergic neuron differentiation
  • positive regulation of endothelial cell migration
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • positive regulation of peptidyl-serine phosphorylation
  • epithelial cell differentiation
  • positive regulation of vascular endothelial growth factor receptor signaling pathway
  • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
  • positive regulation of epithelial cell proliferation
  • outflow tract morphogenesis
  • VEGF-activated neuropilin signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • heart morphogenesis
  • positive regulation of histone deacetylase activity
  • growth
  • positive regulation of branching involved in ureteric bud morphogenesis
  • response to hypoxia
  • positive regulation of mesenchymal cell proliferation
  • mesoderm development
  • regulation of cell shape
  • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
  • activation of protein kinase activity
  • vascular endothelial growth factor receptor signaling pathway
  • monocyte differentiation
  • positive regulation of protein complex assembly
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of blood vessel endothelial cell migration
  • basophil chemotaxis
  • vasculogenesis
  • tube formation
  • platelet activation
  • cellular response to hypoxia
  • positive regulation of cell migration involved in sprouting angiogenesis
  • cardiac vascular smooth muscle cell development
  • platelet degranulation
  • positive chemotaxis
  • post-embryonic camera-type eye development
  • lactation
  • positive regulation of angiogenesis
  • eye photoreceptor cell development
  • cardiac muscle fiber development
  • coronary vein morphogenesis
  • nervous system development
  • induction of positive chemotaxis
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • in utero embryonic development
  • positive regulation of gene expression
Components
  • proteinaceous extracellular matrix
  • cytoplasm
  • secretory granule
  • membrane
  • extracellular region
  • extracellular space
  • cell surface
  • platelet alpha granule lumen
General FunctionVascular endothelial growth factor receptor binding
Specific FunctionGrowth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181971
UniProtKB IDP15692
UniProtKB Entry NameVEGFA_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021644|Vascular endothelial growth factor A (VEGFA)
CTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGG
CGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGC
GGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGC
TGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCG
AGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAG
AAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACG
GGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCC
CGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCC
CACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACC
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT
AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC
CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG
ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA
AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
GenBank Gene IDM32977
GeneCard IDNot Available
GenAtlas IDVEGF
HGNC IDHGNC:12680
Chromosome Location6
Locus6p12
References
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