Vascular endothelial growth factor A

NameVascular endothelial growth factor A
Synonyms
  • Vascular permeability factor
  • VEGF
  • VEGF-A
  • VPF
Gene NameVEGFA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000325|Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Number of residues232
Molecular Weight27042.205
Theoretical pI9.08
GO Classification
Functions
  • extracellular matrix binding
  • platelet-derived growth factor receptor binding
  • neuropilin binding
  • receptor agonist activity
  • vascular endothelial growth factor receptor 2 binding
  • protein homodimerization activity
  • protein heterodimerization activity
  • heparin binding
  • identical protein binding
  • fibronectin binding
  • vascular endothelial growth factor receptor 1 binding
  • vascular endothelial growth factor receptor binding
  • growth factor activity
  • cytokine activity
  • chemoattractant activity
Processes
  • positive regulation of vascular endothelial growth factor receptor signaling pathway
  • coronary artery morphogenesis
  • positive regulation of epithelial cell proliferation
  • positive regulation of vascular permeability
  • positive regulation of peptidyl-serine phosphorylation
  • positive regulation of positive chemotaxis
  • positive regulation of retinal ganglion cell axon guidance
  • growth
  • positive regulation of leukocyte migration
  • positive regulation of focal adhesion assembly
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of protein autophosphorylation
  • positive regulation of p38MAPK cascade
  • regulation of retinal ganglion cell axon guidance
  • regulation of cell shape
  • ovarian follicle development
  • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
  • positive regulation of cellular component movement
  • response to hypoxia
  • vascular endothelial growth factor receptor signaling pathway
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • positive regulation of cell adhesion
  • positive regulation of ERK1 and ERK2 cascade
  • dopaminergic neuron differentiation
  • outflow tract morphogenesis
  • VEGF-activated neuropilin signaling pathway
  • platelet activation
  • epithelial cell differentiation
  • cellular response to hypoxia
  • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
  • platelet degranulation
  • positive regulation of branching involved in ureteric bud morphogenesis
  • lactation
  • heart morphogenesis
  • positive regulation of angiogenesis
  • positive regulation of histone deacetylase activity
  • nervous system development
  • activation of protein kinase activity
  • in utero embryonic development
  • positive regulation of mesenchymal cell proliferation
  • positive regulation of gene expression
  • mesoderm development
  • positive regulation of cell proliferation
  • positive regulation of blood vessel endothelial cell migration
  • monocyte differentiation
  • patterning of blood vessels
  • positive regulation of protein complex assembly
  • positive regulation of cell migration involved in sprouting angiogenesis
  • basophil chemotaxis
  • positive regulation of peptidyl-tyrosine phosphorylation
  • vasculogenesis
  • cell maturation
  • tube formation
  • kidney development
  • eye photoreceptor cell development
  • cardiac vascular smooth muscle cell development
  • positive regulation of protein phosphorylation
  • positive chemotaxis
  • positive regulation of endothelial cell proliferation
  • post-embryonic camera-type eye development
  • negative regulation of transcription from RNA polymerase II promoter
  • cardiac muscle fiber development
  • coronary vein morphogenesis
  • induction of positive chemotaxis
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • angiogenesis
  • cell migration involved in sprouting angiogenesis
  • lymph vessel morphogenesis
  • positive regulation of cell division
  • artery morphogenesis
  • blood coagulation
  • mammary gland alveolus development
  • commissural neuron axon guidance
  • positive regulation of protein kinase D signaling
  • positive regulation of cell migration
  • positive regulation of neuroblast proliferation
  • regulation of transcription from RNA polymerase II promoter
  • macrophage differentiation
  • positive regulation of MAP kinase activity
  • positive regulation of protein localization to early endosome
  • lung development
  • positive regulation of receptor internalization
  • cellular response to vascular endothelial growth factor stimulus
  • positive regulation of axon extension involved in axon guidance
  • branching morphogenesis of an epithelial tube
  • regulation of cGMP metabolic process
  • positive regulation of mast cell chemotaxis
  • primitive erythrocyte differentiation
  • negative regulation of apoptotic process
  • surfactant homeostasis
  • positive regulation of protein kinase C signaling
  • positive regulation of peptidyl-tyrosine autophosphorylation
  • endothelial cell chemotaxis
  • positive regulation of CREB transcription factor activity
  • positive regulation of endothelial cell migration
  • camera-type eye morphogenesis
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • vascular endothelial growth factor signaling pathway
Components
  • extracellular space
  • cell surface
  • platelet alpha granule lumen
  • cytoplasm
  • secretory granule
  • membrane
  • proteinaceous extracellular matrix
  • extracellular region
General FunctionVascular endothelial growth factor receptor binding
Specific FunctionGrowth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181971
UniProtKB IDP15692
UniProtKB Entry NameVEGFA_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021644|Vascular endothelial growth factor A (VEGFA)
CTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGG
CGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGC
GGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGC
TGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCG
AGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAG
AAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACG
GGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCC
CGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCC
CACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACC
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT
AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC
CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG
ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA
AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
GenBank Gene IDM32977
GeneCard IDNot Available
GenAtlas IDVEGF
HGNC IDHGNC:12680
Chromosome Location6
Locus6p12
References
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