NameNAD(P)H dehydrogenase [quinone] 1
Synonyms
  • 1.6.5.2
  • Azoreductase
  • DIA4
  • DT-diaphorase
  • DTD
  • Menadione reductase
  • NAD(P)H:quinone oxidoreductase 1
  • NMOR1
  • Phylloquinone reductase
  • QR1
  • Quinone reductase 1
Gene NameNQO1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002355|NAD(P)H dehydrogenase [quinone] 1
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
Number of residues274
Molecular Weight30867.405
Theoretical pI9.34
GO Classification
Functions
  • cytochrome-b5 reductase activity, acting on NAD(P)H
  • identical protein binding
  • poly(A) RNA binding
  • NAD(P)H dehydrogenase (quinone) activity
  • superoxide dismutase activity
Processes
  • negative regulation of catalytic activity
  • response to estradiol
  • synaptic transmission, cholinergic
  • polyamine metabolic process
  • response to toxic substance
  • xenobiotic metabolic process
  • response to nutrient
  • response to ethanol
  • aging
  • regulation of cellular amino acid metabolic process
  • nitric oxide biosynthetic process
  • cellular nitrogen compound metabolic process
  • positive regulation of neuron apoptotic process
  • small molecule metabolic process
Components
  • cytosol
  • extracellular exosome
  • neuronal cell body
  • cytoplasm
General FunctionSuperoxide dismutase activity
Specific FunctionThe enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID189246
UniProtKB IDP15559
UniProtKB Entry NameNQO1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016341|NAD(P)H dehydrogenase [quinone] 1 (NQO1)
ATGGTCGGCAGAAGAGCACTGATCGTACTGGCTCACTCAGAGAGGACGTCCTTCAACTAT
GCCATGAAGGAGGCTGCTGCAGCGGCTTTGAAGAAGAAAGGATGGGAGGTGGTGGAGTCG
GACCTCTATGCCATGAACTTCAATCCCATCATTTCCAGAAAGGACATCACAGGTAAACTG
AAGGACCCTGCGAACTTTCAGTATCCTGCCGAGTCTGTTCTGGCTTATAAAGAAGGCCAT
CTGAGCCCAGATATTGTGGCTGAACAAAAGAAGCTGGAAGCCGCAGACCTTGTGATATTC
CAGTTCCCCCTGCAGTGGTTTGGAGTCCCTGCCATTCTGAAAGGCTGGTTTGAGCGAGTG
TTCATAGGAGAGTTTGCTTACACTTACGCTGCCATGTATGACAAAGGACCCTTCCGGAGT
AAGAAGGCAGTGCTTTCCATCACCACTGGTGGCAGTGGCTCCATGTACTCTCTGCAAGGG
ATCCACGGGGACATGAATGTCATTCTCTGGCCAATTCAGAGTGGCATTCTGCATTTCTGT
GGCTTCCAAGTCTTAGAACCTCAACTGACATATAGCATTGGGCACACTCCAGCAGACGCC
CGAATTCAAATCCTGGAAGGATGGAAGAAACGCCTGGAGAATATTTGGGATGAGACACCA
CTGTATTTTGCTCCAAGCAGCCTCTTTGACCTAAACTTCCAGGCAGGATTCTTAATGAAA
AAAGAGGTACAGGATGAGGAGAAAAACAAGAAATTTGGCCTTTCTGTGGGCCATCACTTG
GGCAAGTCCATCCCAACTGACAACCAGATCAAAGCTAGAAAATGA
GenBank Gene IDJ03934
GeneCard IDNot Available
GenAtlas IDNQO1
HGNC IDHGNC:2874
Chromosome Location16
Locus16q22.1
References
  1. Jaiswal AK, McBride OW, Adesnik M, Nebert DW: Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. J Biol Chem. 1988 Sep 25;263(27):13572-8. 2843525
  2. Jaiswal AK: Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. Biochemistry. 1991 Nov 5;30(44):10647-53. 1657151
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