Fatty acid-binding protein, adipocyte

NameFatty acid-binding protein, adipocyte
Synonyms
  • A-FABP
  • Adipocyte lipid-binding protein
  • Adipocyte-type fatty acid-binding protein
  • AFABP
  • ALBP
  • Fatty acid-binding protein 4
Gene NameFABP4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016343|Fatty acid-binding protein, adipocyte
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKN
TEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVM
KGVTSTRVYERA
Number of residues132
Molecular Weight14718.815
Theoretical pI7.25
GO Classification
Functions
  • transporter activity
  • fatty acid binding
Processes
  • positive regulation of inflammatory response
  • cellular response to lithium ion
  • cholesterol homeostasis
  • negative regulation of transcription, DNA-templated
  • brown fat cell differentiation
  • triglyceride catabolic process
  • cytokine production
  • white fat cell differentiation
  • negative regulation of protein kinase activity
  • small molecule metabolic process
Components
  • lipid particle
  • cytoplasm
  • nucleus
  • cytosol
  • extracellular exosome
General FunctionTransporter activity
Specific FunctionLipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178347
UniProtKB IDP15090
UniProtKB Entry NameFABP4_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016344|Fatty acid-binding protein, adipocyte (FABP4)
ATGTGTGATGCTTTTGTAGGTACCTGGAAACTTGTCTCCAGTGAAAACTTTGATGATTAT
ATGAAAGAAGTAGGAGTGGGCTTTGCCACCAGGAAAGTGGCTGGCATGGCCAAACCTAAC
ATGATCATCAGTGTGAATGGGGATGTGATCACCATTAAATCTGAAAGTACCTTTAAAAAT
ACTGAGATTTCCTTCATACTGGGCCAGGAATTTGACGAAGTCACTGCAGATGACAGGAAA
GTCAAGAGCACCATAACCTTAGATGGGGGTGTCCTGGTACATGTGCAGAAATGGGATGGA
AAATCAACCACCATAAAGAGAAAACGAGAGGATGATAAACTGGTGGTGGAATGCGTCATG
AAAGGCGTCACTTCCACGAGAGTTTATGAGAGAGCATAA
GenBank Gene IDJ02874
GeneCard IDNot Available
GenAtlas IDFABP4
HGNC IDHGNC:3559
Chromosome Location8
Locus8q21
References
  1. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA: Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry. 1989 Oct 31;28(22):8683-90. 2481498
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