Solute carrier family 2, facilitated glucose transporter member 4

NameSolute carrier family 2, facilitated glucose transporter member 4
Synonyms
  • Glucose transporter type 4, insulin-responsive
  • GLUT-4
  • GLUT4
Gene NameSLC2A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001780|Solute carrier family 2, facilitated glucose transporter member 4
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAV
LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI
VIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPA
RKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL
SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM
CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQIS
AAFHRTPSLLEQEVKPSTELEYLGPDEND
Number of residues509
Molecular Weight54786.79
Theoretical pI6.94
GO Classification
Functions
  • glucose transmembrane transporter activity
  • D-glucose transmembrane transporter activity
Processes
  • cellular response to hypoxia
  • response to ethanol
  • brown fat cell differentiation
  • small molecule metabolic process
  • glucose transport
  • carbohydrate metabolic process
  • cellular response to osmotic stress
  • glucose homeostasis
  • hexose transport
  • transmembrane transport
  • glucose transmembrane transport
  • membrane organization
  • amylopectin biosynthetic process
  • cellular response to insulin stimulus
  • glucose import
Components
  • plasma membrane
  • coated pit
  • vesicle membrane
  • clathrin-coated vesicle
  • cytosol
  • multivesicular body
  • extracellular exosome
  • insulin-responsive compartment
  • perinuclear region of cytoplasm
  • endomembrane system
  • external side of plasma membrane
  • trans-Golgi network transport vesicle
  • integral component of plasma membrane
  • membrane raft
  • T-tubule
  • membrane
General FunctionGlucose transmembrane transporter activity
Specific FunctionInsulin-regulated facilitative glucose transporter.
Pfam Domain Function
Transmembrane Regions25-45 82-102 112-132 143-163 172-192 202-222 288-308 324-344 354-374 385-405 418-438 446-466
GenBank Protein ID307076
UniProtKB IDP14672
UniProtKB Entry NameGTR4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016243|Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)
ATGCCGTCGGGCTTCCAACAGATAGGCTCCGAAGATGGGGAACCCCCTCAGCAGCGAGTG
ACTGGGACCCTGGTCCTTGCTGTGTTCTCTGCGGTGCTTGGCTCCCTGCAGTTTGGGTAC
AACATTGGGGTCATCAATGCCCCTCAGAAGGTGATTGAACAGAGCTACAATGAGACGTGG
CTGGGGAGGCAGGGGCCTGAGGGACCCAGCTCCATCCCTCCAGGCACCCTCACCACCCTC
TGGGCCCTCTCCGTGGCCATCTTTTCCGTGGGCGGCATGATTTCCTCCTTCCTCATTGGT
ATCATCTCTCAGTGGCTTGGAAGGAAAAGGGCCATGCTGGTCAACAATGTCCTGGCGGTG
CTGGGGGGCAGCCTCATGGGCCTGGCCAATGCTGCTGCCTCCTATGAAATGCTCATCCTT
GGACGATTCCTCATTGGCGCCTACTCAGGGCTGACATCAGGGCTGGTGCCCATGTACGTG
GGGGAGATTGCTCCCACTCACCTGCGGGGCGCCCTGGGGACGCTCAACCAACTGGCCATT
GTTATCGGCATTCTGATCGCCCAGGTGCTGGGCTTGGAGTCCCTCCTGGGCACTGCCAGC
CTGTGGCCACTGCTCCTGGGCCTCACAGTGCTACCTGCCCTCCTGCAGCTGGTCCTGCTG
CCCTTCTGTCCCGAGAGCCCCCGCTACCTCTACATCATCCAGAATCTCGAGGGGCCTGCC
AGAAAGAGTCTGAAGCGCCTGACAGGCTGGGCCGATGTTTCTGGAGTGCTGGCTGAGCTG
AAGGATGAGAAGCGGAAGCTGGAGCGTGAGCGGCCACTGTCCCTGCTCCAGCTCCTGGGC
AGCCGTACCCACCGGCAGCCCCTGATCATTGCGGTCGTGCTGCAGCTGAGCCAGCAGCTC
TCTGGCATCAATGCTGTTTTCTATTATTCGACCAGCATCTTCGAGACAGCAGGGGTAGGC
CAGCCTGCCTATGCCACCATAGGAGCTGGTGTGGTCAACACAGTCTTCACCTTGGTCTCG
GTGTTGTTGGTGGAGCGGGCGGGGCGCCGGACGCTCCATCTCCTGGGCCTGGCGGGCATG
TGTGGCTGTGCCATCCTGATGACTGTGGCTCTGCTCCTGCTGGAGCGAGTTCCAGCCATG
AGCTACGTCTCCATTGTGGCCATCTTTGGCTTCGTGGCATTTTTTGAGATTGGCCCTGGC
CCCATTCCTTGGTTCATCGTGGCCGAGCTCTTCAGCCAGGGACCCCGCCCGGCAGCCATG
GCTGTGGCTGGTTTCTCCAACTGGACGAGCAACTTCATCATTGGCATGGGTTTCCAGTAT
GTTGCGGAGGCTATGGGGCCCTACGTCTTCCTTCTATTTGCGGTCCTCCTGCTGGGCTTC
TTCATCTTCACCTTCTTAAGAGTACCTGAAACTCGAGGCCGGACGTTTGACCAGATCTCA
GCTGCCTTCCACCGGACACCCTCTCTTTTAGAGCAGGAGGTGAAACCCAGCACAGAACTT
GAGTATTTAGGGCCAGATGAGAACGACTGA
GenBank Gene IDM20747
GeneCard IDNot Available
GenAtlas IDSLC2A4
HGNC IDHGNC:11009
Chromosome Location17
Locus17p13
References
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