Alcohol dehydrogenase [NADP(+)]

NameAlcohol dehydrogenase [NADP(+)]
Synonyms
  • 1.1.1.2
  • Aldehyde reductase
  • Aldo-keto reductase family 1 member A1
  • ALDR1
  • ALR
Gene NameAKR1A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017416|Alcohol dehydrogenase [NADP(+)]
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY
Number of residues325
Molecular Weight36572.71
Theoretical pI6.79
GO Classification
Functions
  • alditol
  • L-glucuronate reductase activity
  • electron carrier activity
Processes
  • glucose metabolic process
  • xenobiotic metabolic process
  • cellular aldehyde metabolic process
  • glucuronate catabolic process to xylulose 5-phosphate
  • glutathione derivative biosynthetic process
  • aldehyde catabolic process
  • L-ascorbic acid biosynthetic process
  • D-glucuronate catabolic process
  • small molecule metabolic process
  • carbohydrate metabolic process
Components
  • apical plasma membrane
  • extracellular space
  • cytosol
  • extracellular exosome
General FunctionL-glucuronate reductase activity
Specific FunctionCatalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID178481
UniProtKB IDP14550
UniProtKB Entry NameAK1A1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0017417|Alcohol dehydrogenase [NADP(+)] (AKR1A1)
ATGGCGGCTTCCTGTGTTCTACTGCACACTGGGCAGAAGATGCCTCTGATTGGTCTGGGT
ACCTGGAAGAGTGAGCCTGGTCAGGTAAAAGCAGCTGTTAAGTATGCCCTTAGCGTAGGC
TACCGCCACATTGATTGTGCTGCTATCTACGGCAATGAGCCTGAGATTGGGGAGGCCCTG
AAGGAGGACGTGGGACCAGGCAAGGCGGTGCCTCGGGAGGAGCTGTTTGTGACATCCAAG
CTGTGGAACACCAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACTCTGGCT
GACCTCCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTATGCCTTTGAGCGG
GGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCA
GCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGG
CGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAG
TATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACC
TTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTG
CCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGA
GenBank Gene IDJ04794
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:380
Chromosome Location1
Locus1p33-p32
References
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