Beta-3 adrenergic receptor

NameBeta-3 adrenergic receptor
Synonyms
  • ADRB3R
  • B3AR
  • Beta-3 adrenoceptor
  • Beta-3 adrenoreceptor
Gene NameADRB3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010709|Beta-3 adrenergic receptor
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Number of residues408
Molecular Weight43518.615
Theoretical pI9.07
GO Classification
Functions
  • protein homodimerization activity
  • beta3-adrenergic receptor activity
  • epinephrine binding
  • norepinephrine binding
  • beta-adrenergic receptor activity
Processes
  • cell-cell signaling
  • heat generation
  • negative regulation of multicellular organism growth
  • carbohydrate metabolic process
  • response to cold
  • vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
  • activation of adenylate cyclase activity
  • eating behavior
  • energy reserve metabolic process
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • aging
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • temperature homeostasis
  • generation of precursor metabolites and energy
  • positive regulation of MAPK cascade
  • response to antibiotic
  • adenylate cyclase-activating adrenergic receptor signaling pathway
  • brown fat cell differentiation
  • diet induced thermogenesis
Components
  • integral component of plasma membrane
  • nucleus
  • plasma membrane
  • receptor complex
General FunctionProtein homodimerization activity
Specific FunctionBeta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Pfam Domain Function
Transmembrane Regions37-63 73-91 112-133 156-178 204-225 293-314 327-347
GenBank Protein ID178896
UniProtKB IDP13945
UniProtKB Entry NameADRB3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010710|Beta-3 adrenergic receptor (ADRB3)
ATGGCTCCGTGGCCTCACGAGAACAGCTCTCTTGCCCCATGGCCGGACCTCCCCACCCTG
GCGCCCAATACCGCCAACACCAGTGGGCTGCCAGGGGTTCCGTGGGAGGCGGCCCTAGCC
GGGGCCCTGCTGGCGCTGGCGGTGCTGGCCACCGTGGGAGGCAACCTGCTGGTCATCGTG
GCCATCGCCTGGACTCCGAGACTCCAGACCATGACCAACGTGTTCGTGACTTCGCTGGCC
GCAGCCGACCTGGTGATGGGACTCCTGGTGGTGCCGCCGGCGGCCACCTTGGCGCTGACT
GGCCACTGGCCGTTGGGCGCCACTGGCTGCGAGCTGTGGACCTCGGTGGACGTGCTGTGT
GTGACCGCCAGCATCGAAACCCTGTGCGCCCTGGCCGTGGACCGCTACCTGGCTGTGACC
AACCCGCTGCGTTACGGCGCACTGGTCACCAAGCGCTGCGCCCGGACAGCTGTGGTCCTG
GTGTGGGTCGTGTCGGCCGCGGTGTCGTTTGCGCCCATCATGAGCCAGTGGTGGCGCGTA
GGGGCCGACGCCGAGGCGCAGCGCTGCCACTCCAACCCGCGCTGCTGTGCCTTCGCCTCC
AACATGCCCTACGTGCTGCTGTCCTCCTCCGTCTCCTTCTACCTTCCTCTTCTCGTGATG
CTCTTCGTCTACGCGCGGGTTTTCGTGGTGGCTACGCGCCAGCTGCGCTTGCTGCGCGGG
GAGCTGGGCCGCTTTCCGCCCGAGGAGTCTCCGCCGGCGCCGTCGCGCTCTCTGGCCCCG
GCCCCGGTGGGGACGTGCGCTCCGCCCGAAGGGGTGCCCGCCTGCGGCCGGCGGCCCGCG
CGCCTCCTGCCTCTCCGGGAACACCGGGCCCTGTGCACCTTGGGTCTCATCATGGGCACC
TTCACTCTCTGCTGGTTGCCCTTCTTTCTGGCCAACGTGCTGCGCGCCCTGGGGGGCCCC
TCTCTAGTCCCGGGCCCGGCTTTCCTTGCCCTGAACTGGCTAGGTTATGCCAATTCTGCC
TTCAACCCGCTCATCTACTGCCGCAGCCCGGACTTTCGCAGCGCCTTCCGCCGTCTTCTG
TGCCGCTGCGGCCGTCGCCTGCCTCCGGAGCCCTGCGCCGCCGCCCGCCCGGCCCTCTTC
CCCTCGGGCGTTCCTGCGGCCCGGAGCAGCCCAGCGCAGCCCAGGCTTTGCCAACGGCTC
GACGGGGCTTCTTGGGGAGTTTCTTAG
GenBank Gene IDM29932
GeneCard IDNot Available
GenAtlas IDADRB3
HGNC IDHGNC:288
Chromosome Location8
Locus8p12-p11.2
References
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  2. van Spronsen A, Nahmias C, Krief S, Briend-Sutren MM, Strosberg AD, Emorine LJ: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. Eur J Biochem. 1993 May 1;213(3):1117-24. 8389293
  3. Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupre I, Delpech B, Bensaid M, LeFur G, Ferrara P, et al.: Molecular cloning of a human beta 3-adrenergic receptor cDNA. FEBS Lett. 1993 Jun 14;324(2):127-30. 8389717
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