Tartrate-resistant acid phosphatase type 5

NameTartrate-resistant acid phosphatase type 5
Synonyms
  • 3.1.3.2
  • Tartrate-resistant acid ATPase
  • TR-AP
  • TrATPase
  • Type 5 acid phosphatase
Gene NameACP5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017453|Tartrate-resistant acid phosphatase type 5
MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQI
LGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQ
IAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKL
ARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGH
DHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSK
EMTVTYIEASGKSLFKTRLPRRARP
Number of residues325
Molecular Weight36598.47
Theoretical pINot Available
GO Classification
Functions
  • acid phosphatase activity
  • ferrous iron binding
  • ferric iron binding
Processes
  • defense response to Gram-positive bacterium
  • negative regulation of interleukin-12 production
  • negative regulation of nitric oxide biosynthetic process
  • small molecule metabolic process
  • negative regulation of superoxide anion generation
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • negative regulation of inflammatory response
  • response to lipopolysaccharide
  • response to cytokine
  • riboflavin metabolic process
  • bone morphogenesis
  • negative regulation of interleukin-1 beta production
  • negative regulation of tumor necrosis factor production
  • bone resorption
Components
  • integral component of membrane
  • cytosol
  • extracellular exosome
  • lysosome
General FunctionFerrous iron binding
Specific FunctionInvolved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP13686
UniProtKB Entry NamePPA5_HUMAN
Cellular LocationLysosome
Gene sequence
>lcl|BSEQ0017454|Tartrate-resistant acid phosphatase type 5 (ACP5)
ATGGACATGTGGACGGCGCTGCTCATCCTGCAAGCCTTGTTGCTACCCTCCCTGGCTGAT
GGTGCCACCCCTGCCCTGCGCTTTGTAGCCGTGGGTGACTGGGGAGGGGTCCCCAATGCC
CCATTCCACACGGCCCGGGAAATGGCCAATGCCAAGGAGATCGCTCGGACTGTGCAGATC
CTGGGTGCAGACTTCATCCTGTCTCTAGGGGACAATTTTTACTTCACTGGTGTGCAAGAC
ATCAATGACAAGAGGTTCCAGGAGACCTTTGAGGACGTATTCTCTGACCGCTCCCTTCGC
AAAGTGCCCTGGTACGTGCTAGCCGGAAACCATGACCACCTTGGCAATGTCTCTGCCCAG
ATTGCATACTCTAAGATCTCCAAGCGCTGGAACTTCCCCAGCCCTTTCTACCGCCTGCAC
TTCAAGATCCCACAGACCAATGTGTCTGTGGCCATTTTTATGCTGGACACAGTGACACTA
TGTGGCAACTCAGATGACTTCCTCAGCCAGCAGCCTGAGAGGCCCCGAGACGTGAAGCTG
GCCCGCACACAGCTGTCCTGGCTCAAGAAACAGCTGGCGGCGGCCAGGGAGGACTACGTG
CTGGTGGCTGGCCACTACCCCGTGTGGTCCATAGCCGAGCACGGGCCTACCCACTGCCTG
GTCAAGCAGCTACGGCCACTGCTGGCCACATACGGGGTCACTGCCTACCTGTGCGGCCAC
GATCACAATCTGCAGTACCTGCAAGATGAGAATGGCGTGGGCTACGTGCTGAGTGGGGCT
GGGAATTTCATGGACCCCTCAAAGCGGCACCAGCGCAAGGTCCCCAACGGCTATCTGCGC
TTCCACTATGGGACTGAAGACTCACTGGGTGGCTTTGCCTATGTGGAGATCAGCTCCAAA
GAGATGACTGTCACTTACATCGAGGCCTCGGGCAAGTCCCTCTTTAAGACCAGGCTGCCG
AGGCGAGCCAGGCCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:124
Chromosome Location19
LocusNot Available
References
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