NameCytochrome c oxidase subunit 4 isoform 1, mitochondrial
Synonyms
  • COX IV-1
  • COX4
  • Cytochrome c oxidase polypeptide IV
  • Cytochrome c oxidase subunit IV isoform 1
Gene NameCOX4I1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017288|Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQK
ALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMW
QKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK
Number of residues169
Molecular Weight19576.6
Theoretical pI10.12
GO Classification
Functions
  • cytochrome-c oxidase activity
Processes
  • aerobic respiration
  • gene expression
  • small molecule metabolic process
  • transcription initiation from RNA polymerase II promoter
  • cellular metabolic process
  • respiratory electron transport chain
  • response to nutrient
  • hydrogen ion transmembrane transport
  • mitochondrial electron transport, cytochrome c to oxygen
  • generation of precursor metabolites and energy
Components
  • nucleus
  • mitochondrial inner membrane
  • extracellular exosome
  • mitochondrial respiratory chain complex IV
  • mitochondrion
  • membrane
General FunctionCytochrome-c oxidase activity
Specific FunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID180933
UniProtKB IDP13073
UniProtKB Entry NameCOX41_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0017289|Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
ATGTTGGCTACCAGGGTATTTAGCCTAGTTGGCAAGCGAGCAATTTCCACCTCTGTGTGT
GTACGAGCTCATGAAAGTGTTGTGAAGAGCGAAGACTTTTCGCTCCCAGCTTATATGGAT
CGGCGTGACCACCCCTTGCCGGAGGTGGCCCATGTCAAGCACCTGTCTGCCAGCCAGAAG
GCATTGAAGGAGAAGGAGAAGGCCTCCTGGAGCAGCCTCTCCATGGATGAGAAAGTCGAG
TTGTATCGCATTAAGTTCAAGGAGAGCTTTGCTGAGATGAACAGGGGCTCGAACGAGTGG
AAGACGGTTGTGGGCGGTGCCATGTTCTTCATCGGTTTCACCGCGCTCGTTATCATGTGG
CAGAAGCACTATGTGTACGGCCCCCTCCCGCAAAGCTTTGACAAAGAGTGGGTGGCCAAG
CAGACCAAGAGGATGCTGGACATGAAGGTGAACCCCATCCAGGGCTTAGCCTCCAAGTGG
GACTACGAAAAGAACGAGTGGAAGAAGTGA
GenBank Gene IDM21575
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2265
Chromosome Location16
Locus16q22-qter
References
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